Trim71 tripartite motif-containing 71 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim71provided by MGI
Official Full Name: tripartite motif-containing 71provided by MGI
Primary source: MGI:MGI:2685973
See related: Ensembl:ENSMUSG00000079259 AllianceGenome:MGI:2685973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lin41; Gm1127; lin-41; mLin41; mlin-41; 2610206G21Rik
Summary: Enables miRNA binding activity and ubiquitin protein ligase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; miRNA-mediated gene silencing by inhibition of translation; and protein autoubiquitination. Acts upstream of or within neural tube closure; positive regulation of miRNA-mediated gene silencing; and regulation of protein metabolic process. Located in P-body. Is expressed in several structures, including branchial arch; extraembryonic component; limb bud; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 2.7), CNS E11.5 (RPKM 0.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 64.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (114340336..114393437, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (114511268..114564369, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein.
Title: Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein.
TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells.
Title: TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells.
A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation.
Title: A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation.
Different congenital hydrocephalus-associated mutations in Trim71 impair stem cell differentiation via distinct gain-of-function mechanisms.
Title: Different congenital hydrocephalus-associated mutations in Trim71 impair stem cell differentiation via distinct gain-of-function mechanisms.
Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs.
Title: Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs.
mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation.
Title: mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation.
A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells.
Title: A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells.
LIN41 interacts with p53, controls its abundance by ubiquitination and antagonizes p53-dependent pro-apoptotic and pro-differentiation responses. In vivo, lack of LIN41 is associated with upregulation of Grhl3 and widespread caspase-3 activation, 2 downstream effectors of p53 with essential roles in neural tube closure.
Title: The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation.
suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Title: Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.
Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
Title: The RNA-binding protein repertoire of embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548510

NoName (e-PCR)
- UniSTS:236268

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA-mediated gene silencing by inhibition of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of miRNA-mediated gene silencing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM71

Names: RING-type E3 ubiquitin transferase TRIM71; lin-41 homolog; protein lin-41 homolog; tripartite motif-containing protein 71

NP_001035968.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042503.2 → NP_001035968.1 E3 ubiquitin-protein ligase TRIM71

See identical proteins and their annotated locations for NP_001035968.1

Status: VALIDATED

Source sequence(s)

AC164109

Consensus CDS

CCDS40793.1

UniProtKB/Swiss-Prot

Q1PSW8

Related

ENSMUSP00000107447.2, ENSMUST00000111816.3

Conserved Domains (6) summary

smart00557
Location:471 → 568

IG_FLMN; Filamin-type immunoglobulin domains

cd14954
Location:571 → 855

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00630
Location:469 → 564

Filamin; Filamin/ABP280 repeat

pfam00643
Location:265 → 298

zf-B_box; B-box zinc finger

sd00039
Location:691 → 727

7WD40; WD40 repeat [structural motif]

cl23765
Location:301 → 431

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits