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    Tra2a transformer 2 alpha [ Mus musculus (house mouse) ]

    Gene ID: 101214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tra2aprovided by MGI
    Official Full Name
    transformer 2 alphaprovided by MGI
    Primary source
    MGI:MGI:1933972
    See related
    Ensembl:ENSMUSG00000029817 AllianceGenome:MGI:1933972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mAWMS1; Tra2alpha; TRA2-alpha; TRA-2 alpha; 1500010G04Rik; G430041M01Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; olfactory epithelium; and retina. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 66.1), CNS E14 (RPKM 56.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tra2a in Genome Data Viewer
    Location:
    6 B2.3; 6 23.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49220855..49241182, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49243921..49264248, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_15813 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49158708-49158891 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49186372-49186673 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49214021-49214322 Neighboring gene STARR-seq mESC enhancer starr_15823 Neighboring gene STARR-seq mESC enhancer starr_15824 Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tra2alpha promotes RA induced neural differentiation of P19 cells. Chen X, et al. Neurochem Res, 2005 Feb. PMID 15895831
    2. Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein. Seong JY, et al. Mol Endocrinol, 2002 Nov. PMID 12403832
    3. cDNA cloning and mRNA expression of Transformer 2 (Tra 2) in chicken embryo. Yamamoto I, et al. Biochim Biophys Acta, 2002 Dec 12. PMID 12427554
    4. Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1. Lieberman AP, et al. Biochem Biophys Res Commun, 2001 Mar 30. PMID 11401487
    5. Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1. Liu Y, et al. Sci Rep, 2017 Aug 7. PMID 28785060, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. interaction of Tra2alpha with 9G8 and SRp30c appears to be crucial for ESE-dependent GnRH pre-mRNA splicing, allowing efficient generation of mature mRNA in GnRH-producing cells
      Title: Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.
    2. exonic splicing enhancer-dependent splicing of GnRH mRNA is mediated by tra2alpha
      Title: Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transformer-2 protein homolog alpha
    Names
    nuclear transformer-2 alpha
    transformer 2 alpha homolog
    transformer-2 protein homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347209.2 → NP_001334138.1  transformer-2 protein homolog alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158667
      Consensus CDS
      CCDS85044.1
      UniProtKB/Swiss-Prot
      Q6PFR5
      UniProtKB/TrEMBL
      A0A0N4SVC2
      Related
      ENSMUSP00000145039.2, ENSMUST00000204189.3
      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    2. NM_001362188.2 → NP_001349117.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667
      Conserved Domains (1) summary
      cd12363
      Location:17 → 96
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    3. NM_001406117.1 → NP_001393046.1  transformer-2 protein homolog alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    4. NM_001406118.1 → NP_001393047.1  transformer-2 protein homolog alpha isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    5. NM_001406119.1 → NP_001393048.1  transformer-2 protein homolog alpha isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    6. NM_001406120.1 → NP_001393049.1  transformer-2 protein homolog alpha isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    7. NM_001406121.1 → NP_001393050.1  transformer-2 protein homolog alpha isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    8. NM_001406122.1 → NP_001393051.1  transformer-2 protein homolog alpha isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    9. NM_001406123.1 → NP_001393052.1  transformer-2 protein homolog alpha isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    10. NM_001406124.1 → NP_001393053.1  transformer-2 protein homolog alpha isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    11. NM_001406125.1 → NP_001393054.1  transformer-2 protein homolog alpha isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5
      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    12. NM_001406126.1 → NP_001393055.1  transformer-2 protein homolog alpha isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    13. NM_001406127.1 → NP_001393056.1  transformer-2 protein homolog alpha isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    14. NM_001406128.1 → NP_001393057.1  transformer-2 protein homolog alpha isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    15. NM_001406129.1 → NP_001393058.1  transformer-2 protein homolog alpha isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    16. NM_001406130.1 → NP_001393059.1  transformer-2 protein homolog alpha isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    17. NM_001406131.1 → NP_001393060.1  transformer-2 protein homolog alpha isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    18. NM_001406132.1 → NP_001393061.1  transformer-2 protein homolog alpha isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    19. NM_001406133.1 → NP_001393062.1  transformer-2 protein homolog alpha isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5
      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    20. NM_001406134.1 → NP_001393063.1  transformer-2 protein homolog alpha isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    21. NM_001406135.1 → NP_001393064.1  transformer-2 protein homolog alpha isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    22. NM_001406136.1 → NP_001393065.1  transformer-2 protein homolog alpha isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    23. NM_001406137.1 → NP_001393066.1  transformer-2 protein homolog alpha isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    24. NM_001406138.1 → NP_001393067.1  transformer-2 protein homolog alpha isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    25. NM_001406139.1 → NP_001393068.1  transformer-2 protein homolog alpha isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    26. NM_001406140.1 → NP_001393069.1  transformer-2 protein homolog alpha isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    27. NM_001406141.1 → NP_001393070.1  transformer-2 protein homolog alpha isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    28. NM_001406142.1 → NP_001393071.1  transformer-2 protein homolog alpha isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    29. NM_001406143.1 → NP_001393072.1  transformer-2 protein homolog alpha isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    30. NM_001406144.1 → NP_001393073.1  transformer-2 protein homolog alpha isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC158667
      UniProtKB/Swiss-Prot
      Q6PFR5

    31. NM_001406145.1 → NP_001393074.1  transformer-2 protein homolog alpha isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC158667

    32. NM_001406146.1 → NP_001393075.1  transformer-2 protein homolog alpha isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC158667

    33. NM_001406147.1 → NP_001393076.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    34. NM_001406149.1 → NP_001393078.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    35. NM_001406150.1 → NP_001393079.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    36. NM_001406151.1 → NP_001393080.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    37. NM_001406152.1 → NP_001393081.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    38. NM_001406153.1 → NP_001393082.1  transformer-2 protein homolog alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158667

    39. NM_001406154.1 → NP_001393083.1  transformer-2 protein homolog alpha isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC158667

    40. NM_001406155.1 → NP_001393084.1  transformer-2 protein homolog alpha isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC158667

    41. NM_001406156.1 → NP_001393085.1  transformer-2 protein homolog alpha isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC158667

    42. NM_001406157.1 → NP_001393086.1  transformer-2 protein homolog alpha isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC158667

    43. NM_001406158.1 → NP_001393087.1  transformer-2 protein homolog alpha isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC158667

    44. NM_001406159.1 → NP_001393088.1  transformer-2 protein homolog alpha isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC158667

    45. NM_001406160.1 → NP_001393089.1  transformer-2 protein homolog alpha isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC158667

    46. NM_001406161.1 → NP_001393090.1  transformer-2 protein homolog alpha isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC158667

    47. NM_198102.3 → NP_932770.2  transformer-2 protein homolog alpha isoform 1

      See identical proteins and their annotated locations for NP_932770.2

      Status: VALIDATED

      Source sequence(s)
      AC158667
      Consensus CDS
      CCDS39486.1
      UniProtKB/Swiss-Prot
      Q6PFR5
      UniProtKB/TrEMBL
      E9QP00
      Related
      ENSMUSP00000031841.8, ENSMUST00000031841.9
      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49220855..49241182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505243.1 → XP_006505306.1  transformer-2 protein homolog alpha isoform X4

      UniProtKB/Swiss-Prot
      Q6PFR5
      Conserved Domains (1) summary
      cd12363
      Location:145 → 222
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    2. XM_036165704.1 → XP_036021597.1  transformer-2 protein homolog alpha isoform X7

      Conserved Domains (1) summary
      cd12363
      Location:17 → 96
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFR5.1 GenPept UniProtKB/Swiss-Prot:Q6PFR5

    Gene LinkOut

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