Plekhh2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plekhh2provided by MGI
Official Full Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2provided by MGI
Primary source: MGI:MGI:2146813
See related: Ensembl:ENSMUSG00000040852 AllianceGenome:MGI:2146813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA2028; E030001K05
Summary: Enables actin binding activity. Involved in negative regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is expressed in s-shaped body. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 12.4), limb E14.5 (RPKM 7.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 55.02 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (84819303..84929571)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (84511895..84622143)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest a structural and functional role for Plekhh2 in the podocyte foot processes.
Title: Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH136080 (e-PCR)
- UniSTS:210075

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pleckstrin homology domain-containing family H member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357986.1 → NP_001344915.1 pleckstrin homology domain-containing family H member 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC132353, AC139329, BP757711

Consensus CDS

CCDS28999.1

UniProtKB/Swiss-Prot

B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8

Conserved Domains (7) summary

smart00139
Location:954 → 1109

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1122 → 1353

B41; Band 4.1 homologues

COG1196
Location:20 → 252

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1349 → 1447

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:705 → 800

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1119 → 1221

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:803 → 916

PH-like; Pleckstrin homology-like domain
NM_001357987.1 → NP_001344916.1 pleckstrin homology domain-containing family H member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC132353, AC139329, BP757711

Conserved Domains (6) summary

smart00139
Location:651 → 806

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:819 → 1050

B41; Band 4.1 homologues

cd13206
Location:1046 → 1144

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:402 → 497

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cl17171
Location:500 → 613

PH-like; Pleckstrin homology-like domain

cl25732
Location:20 → 252

SMC_N; RecF/RecN/SMC N terminal domain
NM_177606.4 → NP_808274.2 pleckstrin homology domain-containing family H member 2 isoform 1

See identical proteins and their annotated locations for NP_808274.2

Status: VALIDATED

Source sequence(s)

AC132353, AC139329

Consensus CDS

CCDS28999.1

UniProtKB/Swiss-Prot

B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8

Related

ENSMUSP00000039628.6, ENSMUST00000047206.7

Conserved Domains (7) summary

smart00139
Location:954 → 1109

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1122 → 1353

B41; Band 4.1 homologues

COG1196
Location:20 → 252

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1349 → 1447

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:705 → 800

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1119 → 1221

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:803 → 916

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

84819303..84929571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160458.1 → XP_036016351.1 pleckstrin homology domain-containing family H member 2 isoform X1

Conserved Domains (7) summary

smart00139
Location:1003 → 1158

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1171 → 1402

B41; Band 4.1 homologues

COG1196
Location:83 → 301

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1398 → 1496

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:754 → 849

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1168 → 1270

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:852 → 965

PH-like; Pleckstrin homology-like domain
XM_036160460.1 → XP_036016353.1 pleckstrin homology domain-containing family H member 2 isoform X4

Conserved Domains (7) summary

smart00139
Location:889 → 1044

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1057 → 1288

B41; Band 4.1 homologues

COG1196
Location:3 → 187

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1284 → 1382

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:640 → 735

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1054 → 1156

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:738 → 851

PH-like; Pleckstrin homology-like domain
XM_030249636.2 → XP_030105496.1 pleckstrin homology domain-containing family H member 2 isoform X8

Conserved Domains (6) summary

smart00139
Location:395 → 550

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:563 → 794

B41; Band 4.1 homologues

cd13206
Location:790 → 888

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:146 → 241

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:560 → 662

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:244 → 357

PH-like; Pleckstrin homology-like domain
XM_036160462.1 → XP_036016355.1 pleckstrin homology domain-containing family H member 2 isoform X7

Conserved Domains (6) summary

smart00139
Location:407 → 562

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:575 → 806

B41; Band 4.1 homologues

cd13206
Location:802 → 900

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:158 → 253

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:572 → 674

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:256 → 369

PH-like; Pleckstrin homology-like domain
XM_036160461.1 → XP_036016354.1 pleckstrin homology domain-containing family H member 2 isoform X5

Conserved Domains (6) summary

smart00139
Location:742 → 897

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:910 → 1141

B41; Band 4.1 homologues

cd13206
Location:1137 → 1235

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:493 → 588

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:907 → 1009

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:591 → 704

PH-like; Pleckstrin homology-like domain
XM_036160459.1 → XP_036016352.1 pleckstrin homology domain-containing family H member 2 isoform X1

Conserved Domains (7) summary

smart00139
Location:1003 → 1158

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1171 → 1402

B41; Band 4.1 homologues

COG1196
Location:83 → 301

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1398 → 1496

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:754 → 849

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1168 → 1270

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:852 → 965

PH-like; Pleckstrin homology-like domain
XM_006523993.5 → XP_006524056.1 pleckstrin homology domain-containing family H member 2 isoform X2

See identical proteins and their annotated locations for XP_006524056.1

UniProtKB/Swiss-Prot

B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8

Conserved Domains (7) summary

smart00139
Location:954 → 1109

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1122 → 1353

B41; Band 4.1 homologues

COG1196
Location:20 → 252

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1349 → 1447

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:705 → 800

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1119 → 1221

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:803 → 916

PH-like; Pleckstrin homology-like domain
XM_017317381.3 → XP_017172870.1 pleckstrin homology domain-containing family H member 2 isoform X2

UniProtKB/Swiss-Prot

B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8

Conserved Domains (7) summary

smart00139
Location:954 → 1109

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1122 → 1353

B41; Band 4.1 homologues

COG1196
Location:20 → 252

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1349 → 1447

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:705 → 800

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1119 → 1221

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:803 → 916

PH-like; Pleckstrin homology-like domain
XM_011246358.4 → XP_011244660.1 pleckstrin homology domain-containing family H member 2 isoform X6

Conserved Domains (7) summary

smart00139
Location:700 → 855

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:868 → 1099

B41; Band 4.1 homologues

COG1196
Location:83 → 301

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1095 → 1193

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:451 → 546

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:865 → 967

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:549 → 662

PH-like; Pleckstrin homology-like domain
XM_006523995.4 → XP_006524058.1 pleckstrin homology domain-containing family H member 2 isoform X3

Conserved Domains (7) summary

smart00139
Location:913 → 1068

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1081 → 1312

B41; Band 4.1 homologues

COG1196
Location:1 → 211

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13206
Location:1308 → 1406

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:664 → 759

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

cd17179
Location:1078 → 1180

FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)

cl17171
Location:762 → 875

PH-like; Pleckstrin homology-like domain