Rictor RPTOR independent companion of MTOR, complex 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rictorprovided by MGI
Official Full Name: RPTOR independent companion of MTOR, complex 2provided by MGI
Primary source: MGI:MGI:1926007
See related: Ensembl:ENSMUSG00000050310 AllianceGenome:MGI:1926007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AVO3; 4921505C17Rik; 6030405M08Rik; D530039E11Rik
Summary: Enables ribosome binding activity. Involved in several processes, including TORC2 signaling; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of protein phosphorylation. Acts upstream of or within several processes, including positive regulation of actin filament polymerization; regulation of establishment of cell polarity; and regulation of protein phosphorylation. Part of TORC2 complex. Is expressed in early conceptus; embryo; and oocyte. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 3.9), cerebellum adult (RPKM 2.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.25 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (6737827..6829882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (6708349..6800401)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Platelet-specific Rictor knockout inhibits platelet production and activation and reduces thrombosis in mice].
Title: [Platelet-specific Rictor knockout inhibits platelet production and activation and reduces thrombosis in mice].
Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis.
Title: Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis.
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.
Title: Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.
miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1alpha and Rictor.
Title: miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1α and Rictor.
Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.
Title: Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.
Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
Title: Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.
Title: Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.
Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
Title: Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
Enhancing Acsl4 in absence of mTORC2/Rictor drove beta-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.
Title: Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126376 (e-PCR)
- UniSTS:163084

AW492497 (e-PCR)
- UniSTS:180730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC2 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rapamycin-insensitive companion of mTOR

Names: AVO3 homolog; mAVO3; protein pianissimo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030168.3 → NP_084444.3 rapamycin-insensitive companion of mTOR

See identical proteins and their annotated locations for NP_084444.3

Status: VALIDATED

Source sequence(s)

AI854883, AK036149, AK173326, BC120903

Consensus CDS

CCDS37032.1

UniProtKB/Swiss-Prot

E9QPE0, Q0VAV4, Q69Z40, Q6PDL2, Q6QI06, Q6RI74, Q8BPH9, Q8CBF2

Related

ENSMUSP00000051809.7, ENSMUST00000061656.8

Conserved Domains (5) summary

pfam14663
Location:747 → 853

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:58 → 437

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:1084 → 1187

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:637 → 740

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:922 → 991

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

6737827..6829882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520003.2 → XP_006520066.1 rapamycin-insensitive companion of mTOR isoform X1

Conserved Domains (5) summary

pfam14663
Location:747 → 853

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:60 → 437

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:1085 → 1187

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:637 → 740

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:922 → 988

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
XM_036159639.1 → XP_036015532.1 rapamycin-insensitive companion of mTOR isoform X2

Conserved Domains (5) summary

pfam14663
Location:465 → 571

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:14 → 155

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:803 → 905

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:355 → 458

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:640 → 709

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5