Kdm2b lysine (K)-specific demethylase 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kdm2bprovided by MGI
Official Full Name: lysine (K)-specific demethylase 2Bprovided by MGI
Primary source: MGI:MGI:1354737
See related: Ensembl:ENSMUSG00000029475 AllianceGenome:MGI:1354737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cxxc2; Fbl10; PCCX2; Fbxl10; Jhdm1b
Summary: The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in CNS E14 (RPKM 10.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.63 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123008727..123127333, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122870664..122989270, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
Title: KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
Title: KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
Title: Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
Title: Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
KDM2 proteins play a widespread and demethylase-independent role in constraining gene expression from CpG islands CGI)-associated gene promoters. KDM2 proteins shape RNA Polymerase II occupancy but not chromatin accessibility at CGI-associated promoters.
Title: KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively
Title: Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.
Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype.
Title: Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts.
These results have not only identified an important epigenetic factor for iHep generation, but also brought new insight into the molecular nature of hepatogenesis and future biomedical applications for liver diseases.
Title: Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b.
this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW822016 (e-PCR)
- UniSTS:207874

NoName (e-PCR)
- UniSTS:235305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 demethylase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K36 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36me/H3K36me2 demethylase activity	IEA Inferred from Electronic Annotation more info
enables histone demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone demethylase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info
enables unmethylated CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fourth ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in initiation of neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain-hindbrain boundary morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in third ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysine-specific demethylase 2B

Names: F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box protein containing leucine repeats 10; F-box/LRR-repeat protein 10; [Histone-H3]-lysine-36 demethylase 1B; jmjC domain-containing histone demethylation protein 1B

NP_001003953.1

EC 1.14.11.27

NP_001365792.1

EC 1.14.11.27

NP_001365793.1

EC 1.14.11.27

NP_001365794.1

EC 1.14.11.27

NP_038938.1

EC 1.14.11.27

XP_006530439.1

EC 1.14.11.27

XP_011246510.1

EC 1.14.11.27

XP_011246511.1

EC 1.14.11.27

XP_011246512.1

EC 1.14.11.27

XP_011246513.1

EC 1.14.11.27

XP_011246514.1

EC 1.14.11.27

XP_011246515.1

EC 1.14.11.27

XP_011246516.1

EC 1.14.11.27

XP_011246517.1

EC 1.14.11.27

XP_011246518.1

EC 1.14.11.27

XP_036021058.1

EC 1.14.11.27

XP_036021059.1

EC 1.14.11.27

XP_036021060.1

EC 1.14.11.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003953.2 → NP_001003953.1 lysine-specific demethylase 2B isoform 1

See identical proteins and their annotated locations for NP_001003953.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK136625, BC065090

Consensus CDS

CCDS39259.1

UniProtKB/Swiss-Prot

Q3V396, Q6P1G2, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6

UniProtKB/TrEMBL

D3YVU7

Related

ENSMUSP00000038229.10, ENSMUST00000046073.16

Conserved Domains (7) summary

cd09293
Location:1080 → 1280

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:151 → 226

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

pfam02008
Location:588 → 624

zf-CXXC; CXXC zinc finger domain

sd00034
Location:1075 → 1099

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:634 → 695

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam12937
Location:1041 → 1081

F-box-like; F-box-like

cl21464
Location:198 → 304

cupin_like; Conserved domain found in cupin and related proteins
NM_001378863.1 → NP_001365792.1 lysine-specific demethylase 2B isoform 3

Status: REVIEWED

Source sequence(s)

AC121564

UniProtKB/TrEMBL

D3YVU7, E9QL25

Related

ENSMUSP00000083376.5, ENSMUST00000086200.11

Conserved Domains (10) summary

PTZ00449
Location:687 → 986

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:1074 → 1274

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:145 → 220

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1069 → 1093

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:628 → 689

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:582 → 618

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:1035 → 1073

F-box-like

pfam17811
Location:297 → 332

JHD; Jumonji helical domain

cl40423
Location:192 → 298

cupin_RmlC-like; RmlC-like cupin superfamily

cl40435
Location:474 → 540

CTD_KDM2A_2B-like; C-terminal domain found in lysine-specific demethylase KDM2A, KDM2B, and similar proteins
NM_001378864.1 → NP_001365793.1 lysine-specific demethylase 2B isoform 4

Status: REVIEWED

Source sequence(s)

AC121564

Conserved Domains (6) summary

PTZ00449
Location:160 → 462

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:561 → 750

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:545 → 569

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:101 → 162

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:55 → 91

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:511 → 549

F-box-like
NM_001378865.1 → NP_001365794.1 lysine-specific demethylase 2B isoform 5

Status: REVIEWED

Source sequence(s)

AC121564

Conserved Domains (5) summary

cd09293
Location:520 → 709

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:504 → 528

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:101 → 162

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:55 → 91

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:470 → 508

F-box-like
NM_013910.2 → NP_038938.1 lysine-specific demethylase 2B isoform 2

See identical proteins and their annotated locations for NP_038938.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks exons in the 5' UTR and 5' coding region and uses an alternate 5' terminal exon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

BC057622, BC065090, BU841175

Consensus CDS

CCDS19657.1

UniProtKB/Swiss-Prot

Q6P1G2

Related

ENSMUSP00000031435.8, ENSMUST00000031435.14

Conserved Domains (5) summary

cd09293
Location:558 → 747

AMN1; Antagonist of mitotic exit network protein 1

pfam02008
Location:55 → 91

zf-CXXC; CXXC zinc finger domain

sd00034
Location:542 → 566

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:101 → 162

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam12937
Location:508 → 548

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

123008727..123127333 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530376.4 → XP_006530439.1 lysine-specific demethylase 2B isoform X4

UniProtKB/TrEMBL

D3YVU4

Related

ENSMUSP00000114052.3, ENSMUST00000118027.8

Conserved Domains (9) summary

cd09293
Location:1042 → 1242

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:151 → 226

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1037 → 1061

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:634 → 695

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:588 → 624

zf-CXXC; CXXC zinc finger domain

pfam10477
Location:718 → 922

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

pfam12937
Location:1003 → 1041

F-box-like

pfam17811
Location:303 → 338

JHD; Jumonji helical domain

cl21464
Location:198 → 297

cupin_like; Conserved domain found in cupin and related proteins
XM_011248210.3 → XP_011246512.1 lysine-specific demethylase 2B isoform X3

UniProtKB/TrEMBL

D3YVU4

Conserved Domains (9) summary

cd09293
Location:1045 → 1245

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:151 → 226

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1040 → 1064

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:634 → 695

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:588 → 624

zf-CXXC; CXXC zinc finger domain

pfam10477
Location:721 → 925

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

pfam12937
Location:1006 → 1044

F-box-like

pfam17811
Location:303 → 338

JHD; Jumonji helical domain

cl21464
Location:198 → 297

cupin_like; Conserved domain found in cupin and related proteins
XM_011248208.3 → XP_011246510.1 lysine-specific demethylase 2B isoform X1

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (9) summary

PTZ00449
Location:693 → 995

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:1083 → 1283

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:151 → 226

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1078 → 1102

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:634 → 695

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:588 → 624

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:1044 → 1082

F-box-like

pfam17811
Location:303 → 338

JHD; Jumonji helical domain

cl21464
Location:198 → 297

cupin_like; Conserved domain found in cupin and related proteins
XM_011248212.4 → XP_011246514.1 lysine-specific demethylase 2B isoform X5

See identical proteins and their annotated locations for XP_011246514.1

UniProtKB/TrEMBL

D3YVU7

Related

ENSMUSP00000114049.2, ENSMUST00000121739.8

Conserved Domains (9) summary

PTZ00449
Location:638 → 940

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:1028 → 1228

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:96 → 171

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1023 → 1047

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:579 → 640

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:533 → 569

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:989 → 1027

F-box-like

pfam17811
Location:248 → 283

JHD; Jumonji helical domain

cl21464
Location:143 → 242

cupin_like; Conserved domain found in cupin and related proteins
XM_011248211.4 → XP_011246513.1 lysine-specific demethylase 2B isoform X5

See identical proteins and their annotated locations for XP_011246513.1

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (9) summary

PTZ00449
Location:638 → 940

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:1028 → 1228

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:96 → 171

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1023 → 1047

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:579 → 640

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:533 → 569

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:989 → 1027

F-box-like

pfam17811
Location:248 → 283

JHD; Jumonji helical domain

cl21464
Location:143 → 242

cupin_like; Conserved domain found in cupin and related proteins
XM_011248209.4 → XP_011246511.1 lysine-specific demethylase 2B isoform X2

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (9) summary

PTZ00449
Location:687 → 989

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:1077 → 1277

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:145 → 220

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:1072 → 1096

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:628 → 689

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:582 → 618

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:1038 → 1076

F-box-like

pfam17811
Location:297 → 332

JHD; Jumonji helical domain

cl21464
Location:192 → 291

cupin_like; Conserved domain found in cupin and related proteins
XM_011248215.2 → XP_011246517.1 lysine-specific demethylase 2B isoform X8

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (9) summary

PTZ00449
Location:607 → 909

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:997 → 1197

AMN1; Antagonist of mitotic exit network protein 1

smart00558
Location:65 → 140

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00034
Location:992 → 1016

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:548 → 609

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:502 → 538

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:958 → 996

F-box-like

pfam17811
Location:217 → 252

JHD; Jumonji helical domain

cl21464
Location:112 → 211

cupin_like; Conserved domain found in cupin and related proteins
XM_036165165.1 → XP_036021058.1 lysine-specific demethylase 2B isoform X7

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (9) summary

PTZ00449
Location:493 → 792

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:880 → 1080

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:875 → 899

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:434 → 495

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:388 → 424

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:841 → 879

F-box-like

pfam17811
Location:103 → 138

JHD; Jumonji helical domain

cd21785
Location:280 → 346

CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

cl40423
Location:1 → 104

cupin_RmlC-like; RmlC-like cupin superfamily
XM_011248214.3 → XP_011246516.1 lysine-specific demethylase 2B isoform X6

See identical proteins and their annotated locations for XP_011246516.1

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (8) summary

PTZ00449
Location:493 → 795

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:883 → 1083

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:878 → 902

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:434 → 495

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:388 → 424

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:844 → 882

F-box-like

pfam17811
Location:103 → 138

JHD; Jumonji helical domain

cl21464
Location:1 → 97

cupin_like; Conserved domain found in cupin and related proteins
XM_011248213.4 → XP_011246515.1 lysine-specific demethylase 2B isoform X6

See identical proteins and their annotated locations for XP_011246515.1

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (8) summary

PTZ00449
Location:493 → 795

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:883 → 1083

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:878 → 902

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:434 → 495

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:388 → 424

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:844 → 882

F-box-like

pfam17811
Location:103 → 138

JHD; Jumonji helical domain

cl21464
Location:1 → 97

cupin_like; Conserved domain found in cupin and related proteins
XM_011248216.3 → XP_011246518.1 lysine-specific demethylase 2B isoform X6

See identical proteins and their annotated locations for XP_011246518.1

UniProtKB/TrEMBL

D3YVU7

Conserved Domains (8) summary

PTZ00449
Location:493 → 795

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:883 → 1083

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:878 → 902

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:434 → 495

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:388 → 424

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:844 → 882

F-box-like

pfam17811
Location:103 → 138

JHD; Jumonji helical domain

cl21464
Location:1 → 97

cupin_like; Conserved domain found in cupin and related proteins
XM_036165167.1 → XP_036021060.1 lysine-specific demethylase 2B isoform X10

Conserved Domains (7) summary

PTZ00449
Location:363 → 662

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:750 → 950

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:745 → 769

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:304 → 365

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:258 → 294

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:711 → 749

F-box-like

cd21785
Location:150 → 216

CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
XM_036165166.1 → XP_036021059.1 lysine-specific demethylase 2B isoform X9

Conserved Domains (7) summary

PTZ00449
Location:363 → 665

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09293
Location:753 → 953

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:748 → 772

LRR_AMN1; leucine-rich repeat [structural motif]

cd15644
Location:304 → 365

PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)

pfam02008
Location:258 → 294

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:714 → 752

F-box-like

cd21785
Location:150 → 216

CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001005866.1: Suppressed sequence

Description

NM_001005866.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.