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    Tdrd12 tudor domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 71981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdrd12provided by MGI
    Official Full Name
    tudor domain containing 12provided by MGI
    Primary source
    MGI:MGI:1919231
    See related
    Ensembl:ENSMUSG00000030491 AllianceGenome:MGI:1919231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ECAT8; repro23; EG434165; G1-476-14; 2410004F06Rik; 2410070K17Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Involved in several processes, including male meiotic nuclear division; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Part of PET complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 4.7), kidney adult (RPKM 0.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tdrd12 in Genome Data Viewer
    Location:
    7 B2; 7 21.37 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35166366..35237206, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35466941..35537784, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18633 Neighboring gene nudix hydrolase 19 Neighboring gene regulator of G-protein signalling 9 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and linkage mapping of an ENU-induced mutant mouse with defective spermatogenesis. Asano Y, et al. Exp Anim, 2009 Oct. PMID 19897936
    2. Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12. Pandey RR, et al. Cell Rep, 2018 Sep 25. PMID 30257204
    3. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Yang Z, et al. Mol Cell, 2016 Jan 7. PMID 26669262, Free PMC Article
    4. Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome". Schimenti JC, et al. Biol Reprod, 2018 Dec 1. PMID 29878059
    5. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Mitsui K, et al. Cell, 2003 May 30. PMID 12787504

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
      Title: Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase TDRD12
    Names
    ES cell associated transcript 8
    ES cell-associated transcript 8 protein
    tudor domain-containing protein 12
    NP_001355316.1
    NP_082310.1
    XP_011249006.1
    XP_011249009.1
    XP_030098858.1
    XP_030098859.1
    XP_030098860.1
    XP_030098861.1
    XP_030098862.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368387.1 → NP_001355316.1  putative ATP-dependent RNA helicase TDRD12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151535
      UniProtKB/Swiss-Prot
      Q9CWU0
      Related
      ENSMUSP00000141796.3, ENSMUST00000193633.6

    2. NM_028034.2 → NP_082310.1  putative ATP-dependent RNA helicase TDRD12 isoform 1

      See identical proteins and their annotated locations for NP_082310.1

      Status: VALIDATED

      Source sequence(s)
      AK010386, AK010714, CJ078592
      Consensus CDS
      CCDS21151.1
      UniProtKB/TrEMBL
      A0A0U1RNL0
      Related
      ENSMUSP00000032701.8, ENSMUST00000032701.14
      Conserved Domains (2) summary
      cd04508
      Location:60 → 109
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:2 → 129
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      35166366..35237206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243001.2 → XP_030098861.1  putative ATP-dependent RNA helicase TDRD12 isoform X3

      UniProtKB/Swiss-Prot
      Q9CWU0
      Conserved Domains (3) summary
      COG0513
      Location:391 → 665
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:3 → 128
      TUDOR; Tudor domain
      cl00175
      Location:1074 → 1178
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    2. XM_030242998.2 → XP_030098858.1  putative ATP-dependent RNA helicase TDRD12 isoform X1

      UniProtKB/TrEMBL
      A0A087WQS9
      Related
      ENSMUSP00000140328.4, ENSMUST00000187190.7
      Conserved Domains (3) summary
      cd06463
      Location:1139 → 1179
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      COG0513
      Location:391 → 729
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:3 → 128
      TUDOR; Tudor domain

    3. XM_030242999.1 → XP_030098859.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

      UniProtKB/Swiss-Prot
      Q9CWU0
      Conserved Domains (3) summary
      COG0513
      Location:353 → 691
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:1 → 90
      TUDOR; Tudor domain
      cl00175
      Location:1100 → 1204
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    4. XM_030243000.1 → XP_030098860.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

      UniProtKB/Swiss-Prot
      Q9CWU0
      Conserved Domains (3) summary
      COG0513
      Location:353 → 691
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:1 → 90
      TUDOR; Tudor domain
      cl00175
      Location:1100 → 1204
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    5. XM_030243002.2 → XP_030098862.1  putative ATP-dependent RNA helicase TDRD12 isoform X4

      Conserved Domains (3) summary
      COG0513
      Location:119 → 457
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:584 → 699
      TUDOR; Tudor domain
      cl00175
      Location:866 → 970
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    6. XM_011250704.4 → XP_011249006.1  putative ATP-dependent RNA helicase TDRD12 isoform X5

      Conserved Domains (2) summary
      COG0513
      Location:391 → 729
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:3 → 128
      TUDOR; Tudor domain

    7. XM_011250707.4 → XP_011249009.1  putative ATP-dependent RNA helicase TDRD12 isoform X6

      Conserved Domains (2) summary
      COG0513
      Location:391 → 692
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00567
      Location:3 → 128
      TUDOR; Tudor domain

    RNA

    1. XR_001778000.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001082581.1: Suppressed sequence

      Description
      NM_001082581.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWU0.2 GenPept UniProtKB/Swiss-Prot:Q9CWU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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