Phf14 PHD finger protein 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phf14provided by MGI
Official Full Name: PHD finger protein 14provided by MGI
Primary source: MGI:MGI:1923539
See related: Ensembl:ENSMUSG00000029629 AllianceGenome:MGI:1923539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0783; 1110001C23Rik; 4932409F11Rik; 5730446A07Rik
Summary: Predicted to enable histone binding activity; histone reader activity; and zinc ion binding activity. Involved in germinal center B cell differentiation. Acts upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hindlimb phalanx; nervous system; and tooth. Orthologous to human PHF14 (PHD finger protein 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 8.4), CNS E14 (RPKM 6.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 5.01 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (11907728..12100155)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (11907725..12100156)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHF14 is required for germinal center B cell development.
Title: PHF14 is required for germinal center B cell development.
PHF14 expression was upregulated in fibrotic models in vivo and in vitro, and the TGF-beta/smad3/PHF14 pathway acted as a self-limiting mechanism in the TGF-beta-dominated renal pro-fibrotic process by suppressing PDGFR-alpha expression.
Title: PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury.
results indicated that PHF14 might be an epigenetic regulator and play an important role in the development of multiple organs in mouse
Title: Depletion of PHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure.
Phf14 acts as a negative regulator of PDGFRalpha expression in mesenchymal cells undergoing normal and abnormal proliferation, and is a potential target for new treatments of lung fibrosis.
Title: Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235386

NoName (e-PCR)
- UniSTS:235387

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in germinal center B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mesenchymal cell proliferation involved in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation involved in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of platelet-derived growth factor receptor-alpha signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PHD finger protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168382.2 → NP_001161854.1 PHD finger protein 14 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC153640, AC153641

Consensus CDS

CCDS51720.1

UniProtKB/Swiss-Prot

Q810Z6, Q8C284, Q8CGF8, Q9D1Q8, Q9D4H9

Related

ENSMUSP00000111173.3, ENSMUST00000115511.9

Conserved Domains (4) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:863 → 911

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
NM_001362122.1 → NP_001349051.1 PHD finger protein 14 isoform 3

Status: VALIDATED

Source sequence(s)

AC153640, AC153641

Conserved Domains (4) summary

cd15561
Location:36 → 92

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:442 → 491

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:585 → 633

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:100 → 213

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
NM_001362123.1 → NP_001349052.1 PHD finger protein 14 isoform 4

Status: VALIDATED

Source sequence(s)

AC153640, AC153641

Conserved Domains (3) summary

cd15561
Location:36 → 92

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:442 → 491

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:100 → 213

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
NM_029404.4 → NP_083680.2 PHD finger protein 14 isoform 2

See identical proteins and their annotated locations for NP_083680.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

AC153640, AC153641

Consensus CDS

CCDS39428.1

UniProtKB/TrEMBL

G5E8S0

Related

ENSMUSP00000111172.2, ENSMUST00000115510.8

Conserved Domains (3) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

11907728..12100155

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505202.5 → XP_006505265.1 PHD finger protein 14 isoform X7

See identical proteins and their annotated locations for XP_006505265.1

Conserved Domains (4) summary

cd15561
Location:36 → 92

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:442 → 491

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:585 → 633

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:100 → 213

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_017321819.3 → XP_017177308.1 PHD finger protein 14 isoform X8

Conserved Domains (4) summary

cd15561
Location:36 → 92

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:442 → 491

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:585 → 633

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:100 → 213

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_030255656.2 → XP_030111516.1 PHD finger protein 14 isoform X3

UniProtKB/Swiss-Prot

Q810Z6, Q8C284, Q8CGF8, Q9D1Q8, Q9D4H9

Conserved Domains (4) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:863 → 911

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_006505197.5 → XP_006505260.1 PHD finger protein 14 isoform X2

See identical proteins and their annotated locations for XP_006505260.1

Conserved Domains (4) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:863 → 911

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_036152388.1 → XP_036008281.1 PHD finger protein 14 isoform X6

UniProtKB/TrEMBL

G5E8S0

Conserved Domains (3) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_011241085.4 → XP_011239387.1 PHD finger protein 14 isoform X4

Conserved Domains (4) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:863 → 911

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_006505196.5 → XP_006505259.1 PHD finger protein 14 isoform X1

See identical proteins and their annotated locations for XP_006505259.1

Conserved Domains (4) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:863 → 911

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_006505201.5 → XP_006505264.1 PHD finger protein 14 isoform X7

See identical proteins and their annotated locations for XP_006505264.1

Conserved Domains (4) summary

cd15561
Location:36 → 92

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:442 → 491

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15563
Location:585 → 633

PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:100 → 213

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
XM_006505198.5 → XP_006505261.1 PHD finger protein 14 isoform X5

Conserved Domains (3) summary

cd15561
Location:314 → 370

PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins

cd15562
Location:720 → 769

PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins

cd15674
Location:378 → 491

ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins