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    SPMIP11 sperm microtubule inner protein 11 [ Homo sapiens (human) ]

    Gene ID: 255411, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SPMIP11provided by HGNC
    Official Full Name
    sperm microtubule inner protein 11provided by HGNC
    Primary source
    HGNC:HGNC:48628
    See related
    Ensembl:ENSG00000257987 AllianceGenome:HGNC:48628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEX49; LINC00935
    Summary
    Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and sperm flagellum. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 4.8) See more
    Orthologs
    mouse all
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    Genomic context

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    See SPMIP11 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48727435..48771459)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48689465..48733487)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49121218..49159573)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4410 Neighboring gene MPRA-validated peak1722 silencer Neighboring gene MPRA-validated peak1723 silencer Neighboring gene cyclin T1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49110605-49111605 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49117404-49118078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161309-49161888 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161889-49162469 Neighboring gene adenylate cyclase 6 Neighboring gene microRNA 4701 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49176393-49177210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49181275-49181819 Neighboring gene ADCY6 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural specializations of the sperm tail. Leung MR, et al. Cell, 2023 Jun 22. PMID 37327785, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27495

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm microtubule inner protein 11
    Names
    long intergenic non-protein coding RNA 935
    testis expressed 49
    testis-expressed protein 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351123.2 → NP_001338052.1  sperm microtubule inner protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC079951, BC036043
      Consensus CDS
      CCDS86296.1
      UniProtKB/Swiss-Prot
      A0A1B0GTD5
      Related
      ENSP00000489652.1, ENST00000548380.6

    2. NM_001351125.2 → NP_001338054.1  sperm microtubule inner protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079951, BC036043, BC054859

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48727435..48771459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448926.2 → XP_024304694.1  sperm microtubule inner protein 11 isoform X1

    2. XM_024448927.2 → XP_024304695.1  sperm microtubule inner protein 11 isoform X2

    RNA

    1. XR_002957306.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48689465..48733487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371682.1 → XP_054227657.1  sperm microtubule inner protein 11 isoform X1

    2. XM_054371683.1 → XP_054227658.1  sperm microtubule inner protein 11 isoform X2

    RNA

    1. XR_008488561.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GTD5.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GTD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials