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    Dkk4 dickkopf WNT signaling pathway inhibitor 4 [ Mus musculus (house mouse) ]

    Gene ID: 234130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dkk4provided by MGI
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 4provided by MGI
    Primary source
    MGI:MGI:2385299
    See related
    Ensembl:ENSMUSG00000031535 AllianceGenome:MGI:2385299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dkk-4
    Summary
    Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Dkk4 in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23113701..23117563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22623685..22628018)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135 Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene polymerase (DNA directed), beta Neighboring gene STARR-positive B cell enhancer ABC_E6626 Neighboring gene inhibitor of kappaB kinase beta Neighboring gene predicted gene 15346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway. Liang J, et al. J Biol Chem, 2022 Nov. PMID 36181792, Free PMC Article
    2. The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts. Hiramitsu S, et al. Endocrinology, 2013 Dec. PMID 24105477
    3. Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. Cui CY, et al. PLoS One, 2010 Apr 1. PMID 20386733, Free PMC Article
    4. Genome-wide copy number variation study in anorectal malformations. Wong EH, et al. Hum Mol Genet, 2013 Feb 1. PMID 23108157
    5. Hierarchical patterning modes orchestrate hair follicle morphogenesis. Glover JD, et al. PLoS Biol, 2017 Jul. PMID 28700594, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/beta-catenin negative feedback pathway.
      Title: Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway.
    2. the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
      Title: Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.
    3. sweat gland development shows a relay of regulatory steps initiated by Wnt/beta-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways.
      Title: Involvement of Wnt, Eda and Shh at defined stages of sweat gland development.
    4. These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt/beta-catenin signaling, providing new insights into the relationship between Wnt/beta-catenin signaling and Dkk4 in bone formation.
      Title: The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts.
    5. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations.
      Title: Genome-wide copy number variation study in anorectal malformations.
    6. Dkk4 affects an auxiliary pathway for Eda-independent development of secondary hair
      Title: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
    7. Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 in embryonic eda(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
      Title: Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.
    8. Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis.
      Title: The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25705

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of hair follicle placode formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dickkopf-related protein 4
    Names
    dickkopf homolog 4
    dickkopf-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145592.2 → NP_663567.1  dickkopf-related protein 4 precursor

      See identical proteins and their annotated locations for NP_663567.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121835
      Consensus CDS
      CCDS22180.1
      UniProtKB/Swiss-Prot
      Q8VEJ3
      Related
      ENSMUSP00000033936.7, ENSMUST00000033936.8
      Conserved Domains (2) summary
      pfam06607
      Location:145 → 202
      Prokineticin
      pfam04706
      Location:41 → 91
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23113701..23117563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509098.4 → XP_006509161.1  dickkopf-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006509161.1

      UniProtKB/Swiss-Prot
      Q8VEJ3
      Conserved Domains (2) summary
      pfam06607
      Location:145 → 202
      Prokineticin
      pfam04706
      Location:41 → 91
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEJ3.1 GenPept UniProtKB/Swiss-Prot:Q8VEJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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