Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pyroxd2provided by MGI
Official Full Name: pyridine nucleotide-disulphide oxidoreductase domain 2provided by MGI
Primary source: MGI:MGI:1921830
See related: Ensembl:ENSMUSG00000060224 AllianceGenome:MGI:1921830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3830409H07Rik; 4833409A17Rik
Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 27.6), adrenal adult (RPKM 17.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.56 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (42714296..42741261, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (42725857..42752823, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029011.2 → NP_083287.2 pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

See identical proteins and their annotated locations for NP_083287.2

Status: VALIDATED

Source sequence(s)

AK038414, AK160239, CB573340, CX218741

Consensus CDS

CCDS37991.1

UniProtKB/Swiss-Prot

E9QPD2, Q3U4I7, Q8CAN2, Q9D630

UniProtKB/TrEMBL

A0A494BA58

Related

ENSMUSP00000075825.4, ENSMUST00000076505.4

Conserved Domains (2) summary

COG1233
Location:33 → 580

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

cl21454
Location:35 → 578

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

42714296..42741261 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161713.1 → XP_036017606.1 pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A494BA58

Conserved Domains (1) summary

COG1233
Location:33 → 632

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
XM_036161714.1 → XP_036017607.1 pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A494BA58

Conserved Domains (1) summary

COG1233
Location:33 → 629

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
XM_011247383.4 → XP_011245685.1 pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A494BA58

Conserved Domains (1) summary

COG1233
Location:33 → 583

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]