Trim7 tripartite motif-containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim7provided by MGI
Official Full Name: tripartite motif-containing 7provided by MGI
Primary source: MGI:MGI:2137353
See related: Ensembl:ENSMUSG00000040350 AllianceGenome:MGI:2137353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in antiviral innate immune response. Located in cytoplasm and nucleus. Orthologous to human TRIM7 (tripartite motif containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 20.2), spleen adult (RPKM 18.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.2; 11 28.8 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (48716965..48742019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (48826138..48851192)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Title: TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Title: Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
findings suggested a novel function of RNF90 in innate immunity.
Title: RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
TRIM7 may facilitate the TLR4-mediated innate response via its E3 ligase domain in macrophages.
Title: E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages.
GNIP1 is an ubiquitin ligase with a markedly glycogenic effect in skeletal muscle.
Title: GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM7

Names: glycogenin-interacting protein; tripartite motif protein 7; tripartite motif-containing protein 7

NP_001334375.1

EC 2.3.2.27

NP_444396.2

EC 2.3.2.27

XP_006534631.1

EC 2.3.2.27

XP_006534632.1

EC 2.3.2.27

XP_006534634.1

EC 2.3.2.27

XP_006534636.1

EC 2.3.2.27

XP_006534637.1

EC 2.3.2.27

XP_006534638.1

EC 2.3.2.27

XP_006534639.1

EC 2.3.2.27

XP_006534640.1

EC 2.3.2.27

XP_011247635.1

EC 2.3.2.27

XP_017170349.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347446.1 → NP_001334375.1 E3 ubiquitin-protein ligase TRIM7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

AL645849

Consensus CDS

CCDS83797.1

UniProtKB/Swiss-Prot

Q5NCB6, Q923T7, Q99PQ5

UniProtKB/TrEMBL

Q5NCB7

Related

ENSMUSP00000039011.6, ENSMUST00000046903.6
NM_053166.2 → NP_444396.2 E3 ubiquitin-protein ligase TRIM7 isoform 1

See identical proteins and their annotated locations for NP_444396.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 1, which is shorter at the N-terminus, compared to isoform 2.

Source sequence(s)

AL645849

Consensus CDS

CCDS48779.1

UniProtKB/Swiss-Prot

Q923T7

Related

ENSMUSP00000104836.3, ENSMUST00000109213.9

Conserved Domains (1) summary

cd13740
Location:137 → 303

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

48716965..48742019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534568.4 → XP_006534631.1 E3 ubiquitin-protein ligase TRIM7 isoform X1

UniProtKB/Swiss-Prot

Q5NCB6, Q923T7, Q99PQ5

Conserved Domains (5) summary

COG4942
Location:255 → 357

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:426 → 592

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

cd00162
Location:29 → 80

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19762
Location:129 → 170

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

cl17238
Location:26 → 81

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006534569.4 → XP_006534632.1 E3 ubiquitin-protein ligase TRIM7 isoform X2

UniProtKB/Swiss-Prot

Q5NCB6, Q923T7, Q99PQ5

Conserved Domains (5) summary

COG4942
Location:254 → 356

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:425 → 591

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

cd00162
Location:29 → 80

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19762
Location:129 → 170

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

cl17238
Location:26 → 81

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_011249333.3 → XP_011247635.1 E3 ubiquitin-protein ligase TRIM7 isoform X6

UniProtKB/TrEMBL

B2RR25

Conserved Domains (4) summary

cd00162
Location:29 → 80

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19762
Location:129 → 170

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

cl17238
Location:26 → 81

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

cl21478
Location:158 → 204

ATP-synt_B; ATP synthase B/B' CF(0)
XM_006534573.5 → XP_006534636.1 E3 ubiquitin-protein ligase TRIM7 isoform X4

See identical proteins and their annotated locations for XP_006534636.1

Conserved Domains (2) summary

COG4942
Location:33 → 135

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:204 → 370

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_006534575.5 → XP_006534638.1 E3 ubiquitin-protein ligase TRIM7 isoform X5

See identical proteins and their annotated locations for XP_006534638.1

UniProtKB/Swiss-Prot

Q923T7

Conserved Domains (1) summary

cd13740
Location:137 → 303

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_006534577.5 → XP_006534640.1 E3 ubiquitin-protein ligase TRIM7 isoform X4

See identical proteins and their annotated locations for XP_006534640.1

Conserved Domains (2) summary

COG4942
Location:33 → 135

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:204 → 370

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_006534576.4 → XP_006534639.1 E3 ubiquitin-protein ligase TRIM7 isoform X4

See identical proteins and their annotated locations for XP_006534639.1

Conserved Domains (2) summary

COG4942
Location:33 → 135

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:204 → 370

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_017314860.2 → XP_017170349.1 E3 ubiquitin-protein ligase TRIM7 isoform X4

Conserved Domains (2) summary

COG4942
Location:33 → 135

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:204 → 370

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_006534571.4 → XP_006534634.1 E3 ubiquitin-protein ligase TRIM7 isoform X3

Conserved Domains (2) summary

COG4942
Location:83 → 185

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:254 → 420

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
XM_006534574.5 → XP_006534637.1 E3 ubiquitin-protein ligase TRIM7 isoform X4

See identical proteins and their annotated locations for XP_006534637.1

Conserved Domains (2) summary

COG4942
Location:33 → 135

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13740
Location:204 → 370

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001347436.1: Suppressed sequence

Description

NM_001347436.1: This RefSeq was removed because the transcript was partial at the 5'' end, resulting in a partial CDS.