U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klhl32 kelch-like 32 [ Mus musculus (house mouse) ]

    Gene ID: 212390, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Klhl32provided by MGI
    Official Full Name
    kelch-like 32provided by MGI
    Primary source
    MGI:MGI:3612790
    See related
    Ensembl:ENSMUSG00000040387 AllianceGenome:MGI:3612790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1356; mKIAA1900; D4Ertd389e; 6430524H05Rik
    Summary
    Is expressed in embryo. Orthologous to human KLHL32 (kelch like family member 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), cerebellum adult (RPKM 2.2) and 19 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Klhl32 in Genome Data Viewer
    Location:
    4 A3; 4 10.42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24612559..24851150, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24612559..24851150, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27243 Neighboring gene STARR-seq mESC enhancer starr_09774 Neighboring gene tubulin, beta 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09775 Neighboring gene STARR-seq mESC enhancer starr_09776 Neighboring gene STARR-seq mESC enhancer starr_09777 Neighboring gene STARR-seq mESC enhancer starr_09778 Neighboring gene MMS22-like, DNA repair protein Neighboring gene STARR-seq mESC enhancer starr_09780 Neighboring gene STARR-seq mESC enhancer starr_09781 Neighboring gene predicted gene, 31436 Neighboring gene STARR-seq mESC enhancer starr_09783 Neighboring gene predicted gene, 31379 Neighboring gene predicted gene, 46848 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Phelan SA, et al. Genomics, 1998 Nov 15. PMID 9806838
    2. Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Kudo T, et al. Mol Cell Biol, 2004 May. PMID 15121843, Free PMC Article
    3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kelch-like protein 32
    Names
    BTB and kelch domain containing 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033531.4 → NP_001028703.2  kelch-like protein 32 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK134944, AL671913, AL772223, BF456570, BY281890, CJ093672
      Consensus CDS
      CCDS38702.1
      UniProtKB/TrEMBL
      E9Q7Q2, Q3UY63
      Related
      ENSMUSP00000081839.6, ENSMUST00000084781.6
      Conserved Domains (7) summary
      smart00612
      Location:258 → 313
      Kelch; Kelch domain
      smart00875
      Location:111 → 211
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:30 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:303 → 351
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:32 → 135
      BTB; BTB/POZ domain
      pfam01344
      Location:450 → 496
      Kelch_1; Kelch motif
      pfam13964
      Location:303 → 355
      Kelch_6; Kelch motif

    2. NM_001163020.2 → NP_001156492.1  kelch-like protein 32 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK134944, AL671913, AL772223, BF456570, BY281890, CA556185, CJ093672
      Consensus CDS
      CCDS51131.1
      UniProtKB/TrEMBL
      A2AJX0, B9EIY9
      Related
      ENSMUSP00000103853.4, ENSMUST00000108218.10
      Conserved Domains (7) summary
      smart00612
      Location:291 → 346
      Kelch; Kelch domain
      smart00875
      Location:144 → 244
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:30 → 590
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:336 → 384
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:32 → 136
      BTB; BTB/POZ domain
      pfam01344
      Location:483 → 529
      Kelch_1; Kelch motif
      pfam13964
      Location:336 → 388
      Kelch_6; Kelch motif

    3. NM_001355618.1 → NP_001342547.1  kelch-like protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK134944, AL671913, AL772223, BF456570, BY281890, CJ093672
      Conserved Domains (2) summary
      PHA03098
      Location:54 → 292
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:101 → 149
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      24612559..24851150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163941.1 → XP_036019834.1  kelch-like protein 32 isoform X2

      UniProtKB/TrEMBL
      Q3UY63
      Conserved Domains (4) summary
      PHA03098
      Location:30 → 554
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:300 → 348
      Kelch; KELCH repeat [structural motif]
      cd18471
      Location:103 → 200
      BACK_KLHL32_BKLHD5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32)
      cl38908
      Location:14 → 110
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_030253379.2 → XP_030109239.1  kelch-like protein 32 isoform X4

      Conserved Domains (2) summary
      PHA03098
      Location:54 → 292
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:101 → 149
      Kelch; KELCH repeat [structural motif]

    3. XM_036163940.1 → XP_036019833.1  kelch-like protein 32 isoform X1

      UniProtKB/TrEMBL
      B9EIY9
      Conserved Domains (4) summary
      PHA03098
      Location:19 → 579
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:325 → 373
      Kelch; KELCH repeat [structural motif]
      cd18261
      Location:3 → 135
      BTB_POZ_KLHL32; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32)
      cd18471
      Location:128 → 225
      BACK_KLHL32_BKLHD5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32)

    4. XM_036163943.1 → XP_036019836.1  kelch-like protein 32 isoform X4

      Conserved Domains (2) summary
      PHA03098
      Location:54 → 292
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:101 → 149
      Kelch; KELCH repeat [structural motif]

    5. XM_036163942.1 → XP_036019835.1  kelch-like protein 32 isoform X3

      UniProtKB/TrEMBL
      B9EIY9
      Conserved Domains (4) summary
      PHA03098
      Location:30 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:336 → 384
      Kelch; KELCH repeat [structural motif]
      cd18471
      Location:139 → 236
      BACK_KLHL32_BKLHD5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32)
      cl38908
      Location:14 → 146
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    6. XM_017320094.3 → XP_017175583.1  kelch-like protein 32 isoform X5

      Conserved Domains (2) summary
      cl38908
      Location:14 → 146
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:139 → 209
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools