Rhot1 ras homolog family member T1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhot1provided by RGD
Official Full Name: ras homolog family member T1provided by RGD
Primary source: RGD:1307023
See related: EnsemblRapid:ENSRNOG00000004093 AllianceGenome:RGD:1307023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in establishment of mitochondrion localization by microtubule attachment; regulation of neurotransmitter secretion; and regulation of organelle transport along microtubule. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 280.7), Adrenal (RPKM 216.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25-q26

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65685687..65760682)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65198700..65262807)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67559277..67640622)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
Title: Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
The data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhibition through decreased mitochondrial transport.
Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.
Title: GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
Title: Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitochondrion localization by microtubule attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial outer membrane permeabilization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organelle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial Rho GTPase 1

Names: ras homolog gene family, member T1

NP_001100496.1

EC 3.6.5.-

XP_017452795.1

EC 3.6.5.-

XP_038941952.1

EC 3.6.5.-

XP_038941953.1

EC 3.6.5.-

XP_063125144.1

EC 3.6.5.-

XP_063125145.1

EC 3.6.5.-

XP_063125146.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107026.2 → NP_001100496.1 mitochondrial Rho GTPase 1

See identical proteins and their annotated locations for NP_001100496.1

Status: PROVISIONAL

Source sequence(s)

BC129123

UniProtKB/TrEMBL

A1L1L6, F7EK49

Related

ENSRNOP00000107396.1, ENSRNOT00000137581.1

Conserved Domains (4) summary

cd01892
Location:428 → 605

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

cd01893
Location:16 → 182

Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal

pfam08355
Location:354 → 423

EF_assoc_1; EF hand associated

pfam08356
Location:232 → 316

EF_assoc_2; EF hand associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65685687..65760682

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269076.1 → XP_063125146.1 mitochondrial Rho GTPase 1 isoform X3
XM_063269074.1 → XP_063125144.1 mitochondrial Rho GTPase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K777

Related

ENSRNOP00000074094.1, ENSRNOT00000082685.3
XM_017597306.3 → XP_017452795.1 mitochondrial Rho GTPase 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AVD9, F7EK49

Related

ENSRNOP00000097730.1, ENSRNOT00000112911.2

Conserved Domains (4) summary

cd01892
Location:428 → 593

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

cd01893
Location:16 → 182

Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal

pfam08355
Location:354 → 423

EF_assoc_1; EF hand associated

pfam08356
Location:232 → 316

EF_assoc_2; EF hand associated
XM_039086025.2 → XP_038941953.1 mitochondrial Rho GTPase 1 isoform X6

UniProtKB/TrEMBL

A0A0G2K8T2, F7EK49

Related

ENSRNOP00000074726.2, ENSRNOT00000079696.3

Conserved Domains (4) summary

cd01892
Location:428 → 593

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

cd01893
Location:16 → 182

Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal

pfam08355
Location:354 → 423

EF_assoc_1; EF hand associated

pfam08356
Location:232 → 316

EF_assoc_2; EF hand associated
XM_063269075.1 → XP_063125145.1 mitochondrial Rho GTPase 1 isoform X2

Related

ENSRNOP00000092578.2, ENSRNOT00000108985.2
XM_039086024.2 → XP_038941952.1 mitochondrial Rho GTPase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AGU0, A6HHA9, F7EK49

Conserved Domains (4) summary

cd01892
Location:428 → 594

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

cd01893
Location:16 → 182

Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal

pfam08355
Location:354 → 423

EF_assoc_1; EF hand associated

pfam08356
Location:232 → 316

EF_assoc_2; EF hand associated