Mlc-c Myosin light chain cytoplasmic [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mlc-cprovided by FlyBase
Official Full Name: Myosin light chain cytoplasmicprovided by FlyBase
Primary source: FLYBASE:FBgn0004687
Locus tag: Dmel_CG3201
See related: AllianceGenome:FB:FBgn0004687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3201; Dmel\CG3201; DmMLC_C; ELC; ELC1; mlc-c; MyoII; nmELC
Summary: Enables myosin heavy chain binding activity. Involved in actin filament-based movement. Part of myosin complex. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Orthologous to several human genes including MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5619136..5622539, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5513169..5516572, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila non-muscle myosin II motor activity determines the rate of tissue folding.
Title: Drosophila non-muscle myosin II motor activity determines the rate of tissue folding.
provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin
Title: Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament-based movement	IC Inferred by Curator more info	PubMed
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin V complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin VI complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin VII complex	IPI Inferred from Physical Interaction more info	PubMed

Names: CG3201-PA; CG3201-PB; Mlc-c-PA; Mlc-c-PB; Myosin-II; alkali light chain of non-muscle myosin-II; essential light chain; essential light chain-cytoplasmic; essential myosin light chain-cytoplasmic; myosin; myosin II; myosin light chain-cytoplasmic; non-muscle myosin II; non-muscle myosin-II

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The following sections contain reference sequences that belong to a specific genome build. Explain