l(3)mbt lethal (3) malignant brain tumor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: l(3)mbtprovided by FlyBase
Official Full Name: lethal (3) malignant brain tumorprovided by FlyBase
Primary source: FLYBASE:FBgn0002441
Locus tag: Dmel_CG5954
See related: AllianceGenome:FB:FBgn0002441
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5954; dl(3)MBT; dL(3)mbt; Dmel\CG5954; l(3)malignant braintumor; L(3)mbt; L(3)Mbt; L(3)MBT; L(3)MBT/LIN-61; L3mbt; L3MBT; mbt; MBT
Summary: Enables chromatin insulator sequence binding activity. Involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of preblastoderm mitotic cell cycle; and syncytial nuclear migration. Located in cytoplasm; nucleus; and polytene chromosome. Part of Myb complex and RNA polymerase II transcription regulator complex. Is expressed in several structures, including cephalic furrow; ganglia; gut section; larval optic anlage; and visceral mesoderm derivative. Used to study brain cancer. Orthologous to several human genes including L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3) and L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97F1-97F1; 3-93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27266326..27273273, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (23092048..23098995, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation.
Title: Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation.
L(3)mbt secures tissue identity by preventing the simultaneous expression of original identity markers and tissue-specific misexpression signatures.
Title: L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary.
CRISPR-mediated loss of function of lethal (3) malignant brain tumor [l(3)mbt] leads to ectopic activation of the germ-specific ping-pong cycle in ovarian somatic cells
Title: Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
Data show that L(3)mbt chromosomal targeting requires proteins of a site-specific DNA binding complex Myb-MuvB (MMB core component Mip130)/DREAM.
Title: Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
Data indicate that germline genes, some of which drive oncogenesis in Drosophila melanogaster, are similarly ectopically activated in a wide range of human cancers.
Title: Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.
Data show that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway.
Title: The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of preblastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Myb complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: lethal (3) malignant brain tumor

Names: CG5954-PB; l(3)mbt-PB; lethal(3)malignant brain tumor; lethal(3)malignant brain tumour i; tumor-supressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

27266326..27273273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170330.2 → NP_733209.1 lethal (3) malignant brain tumor [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733209.1

Status: REVIEWED

UniProtKB/TrEMBL

O76931, Q9VB52

Related

FBpp0084545

Conserved Domains (2) summary

smart00561
Location:822 → 918

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

pfam02198
Location:1279 → 1366

SAM_PNT; Sterile alpha motif (SAM)/Pointed domain