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    CG8891 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8891provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031663
    Locus tag
    Dmel_CG8891
    See related
    AllianceGenome:FB:FBgn0031663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8891
    Summary
    Predicted to enable nucleoside triphosphate diphosphatase activity. Predicted to be involved in nucleoside triphosphate catabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8891 in Genome Data Viewer
    Location:
    25B5-25B5; 2-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4978484..4979379, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4978484..4979379, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 05714 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic analysis of the selection response of Drosophila melanogaster to environmental stress: are there links to gene expression and phenotypic traits? Malmendal A, et al. Naturwissenschaften, 2013 May. PMID 23571708
    2. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article
    3. Ultrasensitive proteome analysis using paramagnetic bead technology. Hughes CS, et al. Mol Syst Biol, 2014 Oct 30. PMID 25358341, Free PMC Article
    4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
    5. Identification of Drosophila centromere associated proteins by quantitative affinity purification-mass spectrometry. Barth TK, et al. Data Brief, 2015 Sep. PMID 26306323, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleoside triphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside triphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside triphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8891-PA
    NP_608890.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4978484..4979379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135046.5 → NP_608890.1  uncharacterized protein Dmel_CG8891 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMW7
      Related
      FBpp0078684
      Conserved Domains (1) summary
      cd00515
      Location:5 → 182
      HAM1; NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMW7.1 Q9VMW7

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