Ser Serrate [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Serprovided by FlyBase
Official Full Name: Serrateprovided by FlyBase
Primary source: FLYBASE:FBgn0004197
Locus tag: Dmel_CG6127
See related: AllianceGenome:FB:FBgn0004197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bd; CG6127; CT18858; Dmel\CG6127; mel(3)8; Rpw; ser; SER; std
Summary: Enables Notch binding activity; glycosphingolipid binding activity; and receptor ligand activity. Involved in several processes, including lateral inhibition; post-embryonic animal morphogenesis; and regionalization. Located in several cellular components, including apical cortex; apical plasma membrane; and axolemma. Is expressed in several structures, including dorsal thoracic disc primordium; epithelium; gut section; imaginal disc; and organism subdivision. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease (multiple); multiple sclerosis; and neuromuscular disease (multiple). Orthologous to human JAG1 (jagged canonical Notch ligand 1) and JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97E6-97E8; 3-92 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27172090..27194267, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22997812..23019989, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifications of three novel alleles of Serrate in Drosophila.
Title: Identifications of three novel alleles of Serrate in Drosophila.
Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants.
Title: Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants.
A form of muscular dystrophy associated with pathogenic variants in JAG2.
Title: A form of muscular dystrophy associated with pathogenic variants in JAG2.
Translational Control of Serrate Expression in Drosophila Cells.
Title: Translational Control of Serrate Expression in Drosophila Cells.
Study shows that the trans- and cis- interactions between the ligand Ser and the Notch receptor regulate the cell number and size of the imaginal ring in drosophila.
Title: Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings.
Binding of Notch to ligands of the Delta/DLL and Serrate/JAG families from neighboring cells leads to activation of the signaling pathway and is called trans-activation
Title: Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila.
The Serrate-Notch-Canoe complex mediates interactions between glia and neuroepithelial cells during Drosophila optic lobe development.
Title: A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development.
EGF-like repeat region is responsible for both cis-inhibition and Notch inhibitory properties associated with secreted forms of Serrate.
Title: An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling.
EGFr-8 repeat may directly be involved in ligand-receptor interactions together with EGFr-11 and EGFr-12 or may be crucial for N to adopt a conformation favoring Serrate binding.
Title: A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Notch activation by odorants depends on the Delta/Serrate/Lag2 ligand Delta in select olfactory receptor neurons.
Title: DSL-Notch signaling in the Drosophila brain in response to olfactory stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IDA Inferred from Direct Assay more info	PubMed
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in second mitotic wave involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serrate

Names: CG6127-PA; CG6127-PB; Ser-PA; Ser-PB; beaded; dmSerrate; ripped wing; serratoid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

27172090..27194267 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300629.1 → NP_001287558.1 serrate, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287558.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18168, Q9VB65

UniProtKB/TrEMBL

A0A0B4LIS1

Conserved Domains (4) summary

smart00215
Location:993 → 1053

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:490 → 526

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:220 → 282

DSL; Delta serrate ligand

pfam07657
Location:83 → 161

MNNL; N terminus of Notch ligand
NM_079803.3 → NP_524527.3 serrate, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524527.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P18168, Q9VB65

UniProtKB/TrEMBL

A0A0B4LIS1

Related

FBpp0084498

Conserved Domains (4) summary

smart00215
Location:993 → 1053

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:490 → 526

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:220 → 282

DSL; Delta serrate ligand

pfam07657
Location:83 → 161

MNNL; N terminus of Notch ligand