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    ND-75 NADH dehydrogenase (ubiquinone) 75 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31762, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ND-75provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 75 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017566
    Locus tag
    Dmel_CG2286
    See related
    AllianceGenome:FB:FBgn0017566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2286; Dmel\CG2286; dNDUFS1; ND75; NDUFS1; NDUS1; NUAM
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in cellular respiration; mitochondrial respiratory chain complex I assembly; and reactive oxygen species metabolic process. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and ganglia. Used to study mitochondrial metabolism disease and nuclear type mitochondrial complex I deficiency 5. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ND-75 in Genome Data Viewer
    Location:
    7E1-7E1; 1-23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8248651..8251687, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8142684..8145720, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sniffer Neighboring gene Thioredoxin reductase 1 Neighboring gene uncharacterized protein Neighboring gene Companion of reaper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of mitochondrial disease phenotypic heterogeneity. Granat L, et al. Biol Open, 2024 Feb 15. PMID 38304969, Free PMC Article
    2. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster. Scialò F, et al. Redox Biol, 2020 May. PMID 32146156, Free PMC Article
    3. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hegde VR, et al. Hum Mol Genet, 2014 Sep 1. PMID 24760769, Free PMC Article
    4. Divergence of mitochondrial dna is not corroborated by nuclear dna, morphology, or behavior in Drosophila simulans. Ballard JW, et al. Evolution, 2002 Mar. PMID 11989683
    5. MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Elkholi R, et al. Mol Cell, 2019 May 2. PMID 30879903, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 75 kDa subunit
    Names
    CG2286-PA
    CG2286-PB
    FBpp0071128
    NADH ubiquinone oxidoreductase 75 kDa
    NADH-ubiquinone oxidoreductase 75 kDa subunit
    NADH:ubiquinone oxidoreductase 75 kDa subunit
    NADH:ubiquinone reductase 75 kDa subunit
    NADH:ubiquinone reductase 75-kD subunit precursor
    NADH:ubiquinone reductase 75kD subunit precursor
    ND-75-PA
    ND-75-PB
    NP_511083.1
    NP_727255.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8248651..8251687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078528.3 → NP_511083.1  NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94511, Q9W3H1
      UniProtKB/TrEMBL
      A4V449, Q6NP42
      Related
      FBpp0071128
      Conserved Domains (5) summary
      smart00929
      Location:123 → 163
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      PRK09130
      Location:42 → 722
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:263 → 636
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:671 → 712
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam13510
      Location:40 → 116
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

    2. NM_167152.2 → NP_727255.1  NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94511, Q9W3H1
      UniProtKB/TrEMBL
      A4V449, Q6NP42
      Related
      FBpp0071129
      Conserved Domains (5) summary
      smart00929
      Location:123 → 163
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      PRK09130
      Location:42 → 722
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:263 → 636
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:671 → 712
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam13510
      Location:40 → 116
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V449 A4V449
    Q8MM97 Q8MM97
    Q94511.3 Q94511

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