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    eRF3 eukaryotic translation release factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eRF3provided by FlyBase
    Official Full Name
    eukaryotic translation release factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0020443
    Locus tag
    Dmel_CG6382
    See related
    AllianceGenome:FB:FBgn0020443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6382; delf; deRF3; Dmel\CG6382; dsup35; Dsup35; DSUP35; elf; Elf
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and translation release factor activity. Involved in translational termination. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; gut section; male germline cell; and mesoderm. Orthologous to human GSPT1 (G1 to S phase transition 1) and GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eRF3 in Genome Data Viewer
    Location:
    33E4-33E5; 2-46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12434452..12441279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12434452..12441279)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SR family splicing factor SC35 Neighboring gene Organic anion transporting polypeptide 33Ea Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of a Drosophila homolog of yeast Sup35p disrupts spindle assembly, chromosome segregation, and cytokinesis during male meiosis. Basu J, et al. Cell Motil Cytoskeleton, 1998. PMID 9556329
    2. Evolution of the eukaryotic translation termination system: origins of release factors. Inagaki Y, et al. Mol Biol Evol, 2000 Jun. PMID 10833194
    3. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Chao AT, et al. Genetics, 2003 Oct. PMID 14573473, Free PMC Article
    4. Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure. Lu B, et al. Trends Cell Biol, 2020 Apr. PMID 32200806, Free PMC Article
    5. A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. Harris D, et al. Genetics, 2003 Oct. PMID 14573476, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation termination factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation release factor 3
    Names
    CG6382-PA
    CG6382-PB
    CG6382-PC
    CG6382-PD
    Ef1alpha-like factor
    eRF3-PA
    eRF3-PB
    eRF3-PC
    eRF3-PD
    eukaryotic release factor 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12434452..12441279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273486.1 → NP_001260415.1  eukaryotic translation release factor 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91944, Q9VK85
      Conserved Domains (5) summary
      cd01883
      Location:197 → 416
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:191 → 619
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:12 → 28
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:424 → 505
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:511 → 617
      eRF3_C_III; C-terminal domain of eRF3

    2. NM_057911.4 → NP_477259.1  eukaryotic translation release factor 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91944, Q9VK85
      Related
      FBpp0079951
      Conserved Domains (5) summary
      cd01883
      Location:197 → 416
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:191 → 619
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:12 → 28
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:424 → 505
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:511 → 617
      eRF3_C_III; C-terminal domain of eRF3

    3. NM_001298945.1 → NP_001285874.1  eukaryotic translation release factor 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91944, Q9VK85
      Conserved Domains (5) summary
      cd01883
      Location:197 → 416
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:191 → 619
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:12 → 28
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:424 → 505
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:511 → 617
      eRF3_C_III; C-terminal domain of eRF3

    4. NM_001273487.1 → NP_001260416.1  eukaryotic translation release factor 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD08
      Conserved Domains (4) summary
      cd01883
      Location:73 → 292
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:67 → 495
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      cd04089
      Location:300 → 381
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:387 → 493
      eRF3_C_III; C-terminal domain of eRF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD08 M9PD08
    P91944 P91944
    Q9VK85 Q9VK85

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