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    Cyp4d14 Cytochrome P450 4d14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4d14provided by FlyBase
    Official Full Name
    Cytochrome P450 4d14provided by FlyBase
    Primary source
    FLYBASE:FBgn0023541
    Locus tag
    Dmel_CG3540
    See related
    AllianceGenome:FB:FBgn0023541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4d14; CG3540; Cyp4D14; CYP4D14; Dmel\CG3540; EG:152A3.2
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4d14 in Genome Data Viewer
    Location:
    2E1-2E1; 1-0.8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2173415..2175315, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2067448..2069348, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop Neighboring gene antisense RNA:CR45479 Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
    2. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
    3. Transcriptome analysis of Drosophila suzukii reveals molecular mechanisms conferring pyrethroid and spinosad resistance. Tabuloc CA, et al. Sci Rep, 2024 Aug 27. PMID 39191909, Free PMC Article
    4. Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants. Kasuya J, et al. Neuroscience, 2023 Jun 1. PMID 37004908, Free PMC Article
    5. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4d14
    Names
    CG3540-PA
    CG3540-PB
    Cyp4d14-PA
    Cyp4d14-PB
    cytochrome P450
    NP_001259179.1
    NP_652020.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2173415..2175315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143763.4 → NP_652020.1  cytochrome P450 4d14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46051
      UniProtKB/TrEMBL
      B6IDZ7
      Related
      FBpp0070410
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 489
      p450; Cytochrome P450

    2. NM_001272250.2 → NP_001259179.1  cytochrome P450 4d14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGI4
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 489
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGI4 M9PGI4
    O46051.1 O46051

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