DAAM Dishevelled Associated Activator of Morphogenesis [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DAAMprovided by FlyBase
Official Full Name: Dishevelled Associated Activator of Morphogenesisprovided by FlyBase
Primary source: FLYBASE:FBgn0025641
Locus tag: Dmel_CG14622
See related: AllianceGenome:FB:FBgn0025641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey148; CG14622; daam; Daam; daam1; Daam1; DAAM1; dDaam; dDAAM; Dmel\CG14622; EG:114D9.2
Summary: Predicted to enable actin binding activity and small GTPase binding activity. Involved in several processes, including actin filament organization; axonogenesis; and positive regulation of cellular component organization. Located in several cellular components, including axonal growth cone; presynaptic active zone; and sarcomere. Is expressed in several structures, including brain; gut section; head epidermis primordium; somatic muscle cell; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to several human genes including DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1F2-1F3; 1-0.1 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1289713..1322362, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1183746..1216395, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
Title: FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila.
Title: DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila.
Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
Title: Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
DAAM as an essential for both dextral and sinistral development.
Title: The Drosophila actin nucleator DAAM is essential for left-right asymmetry.
DAAM is an important cytoskeletal effector element of the Wg/Ank2 pathway involved in the determination of basic synaptic structures, and, additionally, that DAAM may couple the active zone scaffold to the presynaptic cytoskeleton.
Title: Microtubule organization in presynaptic boutons relies on the formin DAAM.
Together, these data suggest that, besides operating as an actin assembly factor, DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth.
Title: The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones.
Data suggest that C-terminus, formin-homology domain contributes to DAAM-mediated filopodia formation and actin cytoskeletal dynamics in primary neurons.
Title: The activities of the C-terminal regions of the formin protein disheveled-associated activator of morphogenesis (DAAM) in actin dynamics.
Frl cooperates with DAAM during axon growth in the mushroom body
Title: Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.
This study have shown that the formin dDAAM plays an important role in the regulation of axonal growth and guidance of the Drosophila MB neurons.
Title: The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.
our data suggest that dDAAM is required for the initial assembly of thin filaments, and subsequently it promotes filament elongation by assembling short actin polymers
Title: DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c1311392-1311331 mobile_element_type = transposon:INE-1{}5416

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle thin filament assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tube architecture, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in striated muscle thin filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dishevelled associated activator of morphogenesis

Names: CG14622-PA; CG14622-PB; CG14622-PD; CG14622-PE; CG14622-PF; CG14622-PG; DAAM-PA; DAAM-PB; DAAM-PD; DAAM-PE; DAAM-PF; DAAM-PG; DIA-like; formin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

1289713..1322362 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166875.3 → NP_726723.2 dishevelled associated activator of morphogenesis, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726723.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KW17, Q8IRY0, Q8MT16

Conserved Domains (4) summary

pfam02181
Location:640 → 1018

FH2; Formin Homology 2 Domain

pfam06367
Location:241 → 427

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:39 → 238

Drf_GBD; Diaphanous GTPase-binding Domain

pfam16515
Location:471 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
NM_001272197.1 → NP_001259126.1 dishevelled associated activator of morphogenesis, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259126.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KW17, Q8IRY0, Q8MT16

Conserved Domains (4) summary

pfam02181
Location:640 → 1018

FH2; Formin Homology 2 Domain

pfam06367
Location:241 → 427

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:39 → 238

Drf_GBD; Diaphanous GTPase-binding Domain

pfam16515
Location:471 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
NM_130544.4 → NP_569900.3 dishevelled associated activator of morphogenesis, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_569900.3

Status: REVIEWED

UniProtKB/TrEMBL

Q7YZA4, Q8MT16

Related

FBpp0070231

Conserved Domains (4) summary

pfam02181
Location:601 → 979

FH2; Formin Homology 2 Domain

pfam06367
Location:202 → 388

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:1 → 199

Drf_GBD; Diaphanous GTPase-binding Domain

pfam16515
Location:432 → 520

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
NM_001297842.1 → NP_001284771.1 dishevelled associated activator of morphogenesis, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284771.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KW17, Q8IRY0, Q8MT16

Conserved Domains (4) summary

pfam02181
Location:640 → 1018

FH2; Formin Homology 2 Domain

pfam06367
Location:241 → 427

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:39 → 238

Drf_GBD; Diaphanous GTPase-binding Domain

pfam16515
Location:471 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
NM_166876.3 → NP_726724.1 dishevelled associated activator of morphogenesis, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726724.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KW17, Q8IRY0, Q8MT16

Related

FBpp0070229

Conserved Domains (4) summary

pfam02181
Location:640 → 1018

FH2; Formin Homology 2 Domain

pfam06367
Location:241 → 427

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:39 → 238

Drf_GBD; Diaphanous GTPase-binding Domain

pfam16515
Location:471 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
NM_001201593.2 → NP_001188522.1 dishevelled associated activator of morphogenesis, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188522.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSM5

Conserved Domains (4) summary

pfam02050
Location:779 → 875

FliJ; Flagellar FliJ protein

pfam02181
Location:950 → 1328

FH2; Formin Homology 2 Domain

pfam06367
Location:551 → 737

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:349 → 548

Drf_GBD; Diaphanous GTPase-binding Domain