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    Fen1 Flap endonuclease 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36887, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Fen1provided by FlyBase
    Official Full Name
    Flap endonuclease 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0025832
    Locus tag
    Dmel_CG8648
    See related
    AllianceGenome:FB:FBgn0025832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8648; Dmel\CG8648; DmFEN-1; EG:EG0003.3; fen1; FEN1
    Summary
    Predicted to enable metal ion binding activity and nuclease activity. Predicted to be active in nucleus. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fen1 in Genome Data Viewer
    Location:
    53D13-53D14; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16854025..16855464, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12741530..12742969, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44466 Neighboring gene long non-coding RNA:CR44467 Neighboring gene Integrator 8 Neighboring gene ncRNA Neighboring gene Dek Neighboring gene P-element somatic inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DmGEN, a novel RAD2 family endo-exonuclease from Drosophila melanogaster. Ishikawa G, et al. Nucleic Acids Res, 2004. PMID 15576351, Free PMC Article
    2. PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain. Warbrick E, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705499, Free PMC Article
    3. The base excision repair process: comparison between higher and lower eukaryotes. Hindi NN, et al. Cell Mol Life Sci, 2021 Dec. PMID 34734296, Free PMC Article
    4. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Karres JS, et al. Cell, 2007 Oct 5. PMID 17923093
    5. Nucleotide excision repair endonuclease genes in Drosophila melanogaster. Sekelsky JJ, et al. Mutat Res, 2000 Apr 28. PMID 10812334

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    flap endonuclease 1
    Names
    CG8648-PA
    Fen1-PA
    flap endonuclease-1
    NP_523765.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16854025..16855464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079041.2 → NP_523765.1  flap endonuclease 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K7A9
      Related
      FBpp0086223
      Conserved Domains (3) summary
      cd09907
      Location:222 → 290
      H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
      cd09867
      Location:5 → 344
      PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      PTZ00217
      Location:1 → 363
      PTZ00217; flap endonuclease-1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K7A9.1 Q7K7A9

    Gene LinkOut

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