AstA-R1 Allatostatin A receptor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AstA-R1provided by FlyBase
Official Full Name: Allatostatin A receptor 1provided by FlyBase
Primary source: FLYBASE:FBgn0266429
Locus tag: Dmel_CG2872
See related: AllianceGenome:FB:FBgn0266429
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AlstR; ASR; AST-R; AstA R1; AstAR1; CG2872; D.AlstR1; Dar-1; DAR-1; DAR1; DGR; Dmel\CG2872; EG:121E7.2; GR
Summary: Enables allatostatin receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult brain; adult dorsal fan-shaped body; adult dorsal fan-shaped body tangential neurons; adult head; and neurosecretory cell of pars lateralis. Human ortholog(s) of this gene implicated in nicotine dependence and opiate dependence. Orthologous to several human genes including GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3574536..3666724)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3468569..3560757)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables allatostatin receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables allatostatin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: ASA-receptor; AlstR; AstA-R1-PB; AstA-R1-PD; CG2872-PB; CG2872-PD; allatostatin receptor; galanin receptor

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