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    CG5662 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5662provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030620
    Locus tag
    Dmel_CG5662
    See related
    AllianceGenome:FB:FBgn0030620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5662
    Summary
    Predicted to be involved in mitochondrial outer membrane translocase complex assembly. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5662 in Genome Data Viewer
    Location:
    13B3-13B3; 1-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15210386..15211467)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15104419..15105500)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Huynen MA, et al. Biochim Biophys Acta, 2016 Jan. PMID 26477565
    2. Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster. Chen PL, et al. Nat Commun, 2020 May 22. PMID 32444642, Free PMC Article
    3. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    4. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
    5. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5662-PA
    CG5662-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15210386..15211467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298337.1 → NP_001285266.1  uncharacterized protein Dmel_CG5662, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0ML52, Q8T4F2, Q9VXX4
      Conserved Domains (2) summary
      cd03211
      Location:138 → 266
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      cd03079
      Location:29 → 106
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

    2. NM_132781.2 → NP_573009.1  uncharacterized protein Dmel_CG5662, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0ML52, Q8T4F2, Q9VXX4
      Related
      FBpp0073816
      Conserved Domains (2) summary
      cd03211
      Location:138 → 266
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      cd03079
      Location:29 → 106
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4F2 Q8T4F2

    Gene LinkOut

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