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    Asph Aspartyl beta-hydroxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asphprovided by FlyBase
    Official Full Name
    Aspartyl beta-hydroxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034075
    Locus tag
    Dmel_CG8421
    See related
    AllianceGenome:FB:FBgn0034075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BAH/humbug; CG18658; CG8421; Dmel\CG8421
    Summary
    Predicted to enable peptidyl-aspartic acid 3-dioxygenase activity. Predicted to be involved in regulation of cytosolic calcium ion concentration. Located in endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; larval somatic muscle cell; and mesoderm. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human ASPH (aspartate beta-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Asph in Genome Data Viewer
    Location:
    52E5-52E5; 2-77 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16110331..16116996)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11997836..12004501)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rho1 Neighboring gene Ras-related protein interacting with calmodulin Neighboring gene Juvenile hormone esterase duplication Neighboring gene Juvenile hormone esterase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. Dinchuk JE, et al. J Biol Chem, 2000 Dec 15. PMID 10956665
    2. Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo. Crone EJ, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517331
    3. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
    4. Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects. Knudsen KE, et al. G3 (Bethesda), 2020 Apr 9. PMID 32019873, Free PMC Article
    5. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidyl-aspartic acid 3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-aspartic acid 3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-aspartic acid hydroxylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aspartyl beta-hydroxylase
    Names
    Asph-PA
    Asph-PB
    Asph-PG
    Asph-PH
    Asph-PI
    Asph-PJ
    Asph-PK
    Asph-PL
    CG8421-PA
    CG8421-PB
    CG8421-PG
    CG8421-PH
    CG8421-PI
    CG8421-PJ
    CG8421-PK
    CG8421-PL
    NP_001246357.1
    NP_001246358.1
    NP_001246359.1
    NP_001261020.1
    NP_523757.1
    NP_725525.1
    NP_725526.1
    NP_788365.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16110331..16116996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274091.1 → NP_001261020.1  aspartyl beta-hydroxylase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFS5
      Conserved Domains (3) summary
      COG0457
      Location:610 → 854
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:684 → 714
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:826 → 977
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

    2. NM_001259429.2 → NP_001246358.1  aspartyl beta-hydroxylase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K884, Q95S93

    3. NM_001259430.2 → NP_001246359.1  aspartyl beta-hydroxylase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z397

    4. NM_001259428.2 → NP_001246357.1  aspartyl beta-hydroxylase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7C1
      Conserved Domains (3) summary
      COG0457
      Location:422 → 666
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:496 → 526
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:638 → 789
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

    5. NM_176185.4 → NP_788365.2  aspartyl beta-hydroxylase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788365.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZJ1, Q95S93

    6. NM_079033.5 → NP_523757.1  aspartyl beta-hydroxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KHE2
      Related
      FBpp0086358

    7. NM_166140.4 → NP_725525.1  aspartyl beta-hydroxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GQ82
      Related
      FBpp0086359
      Conserved Domains (3) summary
      COG0457
      Location:404 → 659
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:478 → 508
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:620 → 771
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

    8. NM_166141.4 → NP_725526.1  aspartyl beta-hydroxylase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4J402, Q95S93
      Related
      FBpp0302595
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4J402 A0A0B4J402
    A0A0B4K7C1 A0A0B4K7C1
    A0A0B4K884 A0A0B4K884
    A0A0B4KFS5 A0A0B4KFS5
    A4UZJ1 A4UZJ1
    D1Z397 D1Z397
    Q7KHE2 Q7KHE2
    Q86NU6 Q86NU6
    Q95S93 Q95S93
    Q9GQ82 Q9GQ82

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