Icmt Isoprenylcysteine carboxyl methyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Icmtprovided by FlyBase
Official Full Name: Isoprenylcysteine carboxyl methyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0036336
Locus tag: Dmel_CG11268
See related: AllianceGenome:FB:FBgn0036336
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11268; Dmel\CG11268; Dmel\Ste14; ICMT; ste14; Ste14
Summary: Predicted to enable protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Predicted to be involved in C-terminal protein methylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in organism. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (13018266..13019687)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (13011366..13012787)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
Title: Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in C-terminal protein methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

Names: CG11268-PA; CG11268-PB; Icmt-PA; Icmt-PB; isoprenylcysteine carboxylmethyltransferase

NP_001261793.1

NP_648623.1

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The following sections contain reference sequences that belong to a specific genome build. Explain