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    hd humpty dumpty [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hdprovided by FlyBase
    Official Full Name
    humpty dumptyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086695
    Locus tag
    Dmel_CG2669
    See related
    AllianceGenome:FB:FBgn0086695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2669; Dmel\CG2669; fs(3)272; fs(3)272-9; l(3)82Ff; l(3)82Fk
    Summary
    Involved in eggshell chorion gene amplification and nuclear DNA replication. Located in nucleus. Is expressed in several structures, including CNS glial cell; antennal primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    83A1-83A1; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5372592..5374962, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1198314..1200356, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene uncharacterized protein Neighboring gene 7B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5374811-5374721 mobile_element_type = transposon:I{}5202

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in eggshell chorion gene amplification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    humpty dumpty
    Names
    CG2669-PA
    CG2669-PB
    female sterile(3)272-9
    hd-PA
    hd-PB
    lethal (3) 82Ff
    lethal (3) 82Fk

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5372592..5374962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316495.1 → NP_001303424.1  humpty dumpty, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q540V6, Q9VNA8
      UniProtKB/TrEMBL
      A0A126GUQ3

    2. NM_141274.3 → NP_649531.1  humpty dumpty, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q540V6, Q9VNA8
      UniProtKB/TrEMBL
      A0A126GUQ3
      Related
      FBpp0078445
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUQ3 A0A126GUQ3
    Q9VNA8.1 Q9VNA8

    Gene LinkOut

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    Other Literature Sources
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