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    CG34384 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG34384provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085413
    Locus tag
    Dmel_CG34384
    See related
    AllianceGenome:FB:FBgn0085413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14462; CG2667; CG31187; CG9851; dgk; dgkd; DgkD; DGKd; Dmel\CG34384
    Old locus tag
    CG14462; CG31187; Dmel_CG14462; Dmel_CG31187
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including DGKD (diacylglycerol kinase delta) and DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG34384 in Genome Data Viewer
    Location:
    84E1-84E3; 3-48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7814361..7855392)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3640083..3681114)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sugarlethal Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127 Neighboring gene Arginyl-tRNA synthetase, mitochondrial Neighboring gene mitochondrial ribosomal protein S9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SuUR protein binds to the boundary regions separating forum domains in Drosophila melanogaster. Tchurikov NA, et al. J Biol Chem, 2004 Mar 19. PMID 14702350
    2. Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development. Medina-Yáñez I, et al. Sci Rep, 2020 Dec 10. PMID 33303974, Free PMC Article
    3. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap. Cockcroft S, et al. Biochem J, 2016 Dec 1. PMID 27888240
    4. RNAi screening for kinases and phosphatases identifies FoxO regulators. Mattila J, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18815370, Free PMC Article
    5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG34384-PA
    CG34384-PB
    CG34384-PC
    CG34384-PD
    CG34384-PE
    CG34384-PF
    NP_001097704.1
    NP_001246969.1
    NP_001246970.1
    NP_001246971.1
    NP_001287213.1
    NP_731190.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7814361..7855392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260040.2 → NP_001246969.1  uncharacterized protein Dmel_CG34384, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K634
      Conserved Domains (7) summary
      cd09507
      Location:1851 → 1915
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1854 → 1917
      SAM; Sterile alpha motif
      smart00046
      Location:355 → 477
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:84 → 180
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 175
      PH; PH domain
      pfam00609
      Location:1460 → 1617
      DAGK_acc; Diacylglycerol kinase accessory domain

    2. NM_001260042.1 → NP_001246971.1  uncharacterized protein Dmel_CG34384, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6B6
      Conserved Domains (7) summary
      cd09507
      Location:1869 → 1933
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1872 → 1935
      SAM; Sterile alpha motif
      smart00046
      Location:355 → 477
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:84 → 180
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 175
      PH; PH domain
      pfam00609
      Location:1478 → 1635
      DAGK_acc; Diacylglycerol kinase accessory domain

    3. NM_001104234.4 → NP_001097704.1  uncharacterized protein Dmel_CG34384, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JQ65, Q86NT9
      Conserved Domains (7) summary
      cd09507
      Location:1828 → 1892
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1831 → 1894
      SAM; Sterile alpha motif
      smart00046
      Location:355 → 477
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:84 → 180
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 175
      PH; PH domain
      pfam00609
      Location:1437 → 1594
      DAGK_acc; Diacylglycerol kinase accessory domain

    4. NM_001260041.1 → NP_001246970.1  uncharacterized protein Dmel_CG34384, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6W3
      Conserved Domains (7) summary
      cd09507
      Location:1804 → 1868
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1807 → 1870
      SAM; Sterile alpha motif
      smart00046
      Location:355 → 477
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:84 → 180
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 175
      PH; PH domain
      pfam00609
      Location:1413 → 1570
      DAGK_acc; Diacylglycerol kinase accessory domain

    5. NM_001300284.1 → NP_001287213.1  uncharacterized protein Dmel_CG34384, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHW4
      Conserved Domains (7) summary
      cd09507
      Location:1827 → 1891
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1830 → 1893
      SAM; Sterile alpha motif
      smart00046
      Location:355 → 477
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:84 → 180
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:83 → 175
      PH; PH domain
      pfam00609
      Location:1436 → 1593
      DAGK_acc; Diacylglycerol kinase accessory domain

    6. NM_169197.4 → NP_731190.3  uncharacterized protein Dmel_CG34384, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731190.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QD61
      Conserved Domains (5) summary
      cd09507
      Location:1666 → 1730
      SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits
      smart00109
      Location:34 → 83
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00454
      Location:1669 → 1732
      SAM; Sterile alpha motif
      smart00046
      Location:193 → 315
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00609
      Location:1275 → 1432
      DAGK_acc; Diacylglycerol kinase accessory domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K634 A0A0B4K634
    A0A0B4K6B6 A0A0B4K6B6
    A0A0B4K6W3 A0A0B4K6W3
    A0A0B4LHW4 A0A0B4LHW4
    A8JQ65.1 A8JQ65
    E2QD61 E2QD61

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