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    sals sarcomere length short [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    salsprovided by FlyBase
    Official Full Name
    sarcomere length shortprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051374
    Locus tag
    Dmel_CG31374
    See related
    AllianceGenome:FB:FBgn0051374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14703; CG31374; CG6771; Dmel\CG31374; Sals
    Summary
    Enables actin filament binding activity. Involved in positive regulation of actin filament polymerization and regulation of sarcomere organization. Located in striated muscle thin filament. Is expressed in several structures, including adult brain cell body rind; embryonic/larval fat body; embryonic/larval garland cell; larval muscle system; and muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sals in Genome Data Viewer
    Location:
    86E5-86E6; 3-51 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11437547..11451791, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7263269..7277513, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Exonuclease 3'-5' domain-containing 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4945 stem loop Neighboring gene Peptidoglycan recognition protein LB Neighboring gene long non-coding RNA:CR45581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Activities of the Wiskott-Aldrich Syndrome Homology Region 2 Domains of Sarcomere Length Short (SALS) Protein. Tóth MÁ, et al. J Biol Chem, 2016 Jan 8. PMID 26578512, Free PMC Article
    2. Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. Bai J, et al. Nat Protoc, 2009. PMID 19798083
    3. Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners. Farkas D, et al. PLoS Genet, 2024 Jan. PMID 38198522, Free PMC Article
    4. The Drosophila CG1674 gene encodes a synaptopodin 2-like related protein that localizes to the Z-disc and is required for normal flight muscle development and function. Czajkowski ER, et al. Dev Dyn, 2021 Jan. PMID 32893414, Free PMC Article
    5. The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly. Shwartz A, et al. Elife, 2016 Oct 12. PMID 27731794, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the tandem WH2 domains of SALS are multifunctional regulators of actin dynamics.
      Title: Biochemical Activities of the Wiskott-Aldrich Syndrome Homology Region 2 Domains of Sarcomere Length Short (SALS) Protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sarcomere length short
    Names
    CG31374-PA
    CG31374-PB
    CG31374-PC
    CG31374-PD
    CG31374-PE
    CG31374-PF
    CG31374-PG
    CG31374-PH
    sals-PA
    sals-PB
    sals-PC
    sals-PD
    sals-PE
    sals-PF
    sals-PG
    sals-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11437547..11451791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260121.1 → NP_001247050.1  sarcomere length short, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K633
      Conserved Domains (1) summary
      cl19842
      Location:359 → 445
      DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)

    2. NM_001300359.1 → NP_001287288.1  sarcomere length short, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LI42
      Conserved Domains (1) summary
      cl19842
      Location:383 → 481
      DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)

    3. NM_176460.1 → NP_788637.1  sarcomere length short, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGN4
      Related
      FBpp0081877, FBtr0082401
      Conserved Domains (1) summary
      COG1196
      Location:562 → 811
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_169390.2 → NP_731573.1  sarcomere length short, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGN4
      Related
      FBpp0081875, FBtr0082399
      Conserved Domains (1) summary
      COG1196
      Location:562 → 811
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001170117.2 → NP_001163588.1  sarcomere length short, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58CJ5
      Conserved Domains (1) summary
      COG1196
      Location:532 → 775
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. NM_001260122.1 → NP_001247051.1  sarcomere length short, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58CJ5
      Conserved Domains (1) summary
      COG1196
      Location:532 → 775
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. NM_001260120.1 → NP_001247049.1  sarcomere length short, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58CJ5
      Conserved Domains (1) summary
      COG1196
      Location:532 → 775
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. NM_169391.1 → NP_731574.1  sarcomere length short, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGN5
      Related
      FBpp0081876, FBtr0082400
      Conserved Domains (1) summary
      cl19842
      Location:329 → 415
      DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K633 A0A0B4K633
    A0A0B4LI42 A0A0B4LI42
    Q58CJ5 Q58CJ5
    Q9VGN4 Q9VGN4
    Q9VGN5 Q9VGN5

    Gene LinkOut

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