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    Naa80 N(alpha)-acetyltransferase 80 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa80provided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 80provided by FlyBase
    Primary source
    FLYBASE:FBgn0037747
    Locus tag
    Dmel_CG8481
    See related
    AllianceGenome:FB:FBgn0037747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8481; Dmel\CG8481; DmNAA80; NAA80
    Summary
    Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-aspartic acid acetylation and N-terminal peptidyl-glutamic acid acetylation. Predicted to be active in cytoplasm. Is expressed in several structures, including central brain primordium; ganglia; germline cell; gonad; and ventral nerve cord primordium. Orthologous to human NAA80 (N-alpha-acetyltransferase 80, NatH catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa80 in Genome Data Viewer
    Location:
    85E8-85E8; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9767834..9770027)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5593556..5595749)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Synaptosomal-associated protein 24kDa Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 6 Neighboring gene uncharacterized protein Neighboring gene WHAMM and JMY related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Goris M, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29581307, Free PMC Article
    2. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
    3. Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster. Rajpurohit S, et al. Mol Ecol, 2018 Sep. PMID 30051644, Free PMC Article
    4. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Apidianakis Y, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695583, Free PMC Article
    5. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-aspartic acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-glutamic acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 80
    Names
    CG8481-PA
    CG8481-PB
    Naa80-PA
    Naa80-PB
    NP_001014612.1
    NP_649942.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9767834..9770027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014612.3 → NP_001014612.1  N(alpha)-acetyltransferase 80, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q59DX8, Q8IG82, Q9VH73
      Conserved Domains (1) summary
      pfam00583
      Location:35 → 147
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_141685.5 → NP_649942.1  N(alpha)-acetyltransferase 80, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH73
      Related
      FBpp0081612
      Conserved Domains (1) summary
      pfam00583
      Location:25 → 137
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59DX8.1 Q59DX8

    Gene LinkOut

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