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    betaCOP Coat Protein (coatomer) beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    betaCOPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0008635
    Locus tag
    Dmel_CG6223
    See related
    AllianceGenome:FB:FBgn0008635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.GH09317; BcDNA:GH09317; bcop; Bcop; beta COP; Beta Cop; beta-Cop; beta-COP; beta-CopII; betaCop; BetaCop; CG6223; COPI; Dmel\CG6223
    Summary
    Predicted to enable structural molecule activity. Involved in regulation of lipid storage. Located in Golgi apparatus. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic cortex; and embryonic dorsal epidermis. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See betaCOP in Genome Data Viewer
    Location:
    17A9-17A9; 1-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18381549..18385242, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18275582..18279275, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclic-AMP response element binding protein B Neighboring gene porcupine Neighboring gene uncharacterized protein Neighboring gene Transferrin 1 Neighboring gene 5' nucleotidase B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Location of Golgi membranes with reference to dividing nuclei in syncytial Drosophila embryos. Ripoche J, et al. Proc Natl Acad Sci U S A, 1994 Mar 1. PMID 8127899, Free PMC Article
    2. commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein. Tear G, et al. Neuron, 1996 Mar. PMID 8785048
    3. Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Hunter C, et al. Mol Biol Cell, 2002 Jan. PMID 11809829, Free PMC Article
    4. Sorting out adaptors. Lewin DA, et al. Biochim Biophys Acta, 1998 Feb 4. PMID 9531969
    5. The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake. Southon A, et al. Int J Biochem Cell Biol, 2011 Jan. PMID 21034850

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral entry into host cell HMP PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coat protein (coatomer) beta
    Names
    CG6223-PA
    COPI beta subunit
    beta coatomer protein
    beta-coatomer protein
    betaCOP-PA
    betaCop

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18381549..18385242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078676.4 → NP_523400.1  coat protein (coatomer) beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45437, Q9VWV7, Q9Y116
      Related
      FBpp0074348
      Conserved Domains (3) summary
      pfam01602
      Location:17 → 562
      Adaptin_N; Adaptin N terminal region
      pfam07718
      Location:678 → 820
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:826 → 953
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45437.2 P45437

    Gene LinkOut

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