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    Prx4 Peroxiredoxin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53577, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Prx4provided by FlyBase
    Official Full Name
    Peroxiredoxin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0040308
    Locus tag
    Dmel_CG1274
    See related
    AllianceGenome:FB:FBgn0040308
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1274; CG1274; Dmel\CG1274; dPRDX4; dPrx4; DPx-4156; DPx4156; Jafrac; Jafrac-2; jafrac2; Jafrac2; JafRac2; Prx4156; thioredoxin peroxidase 2 isoform A
    Summary
    Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cellular response to cold; hydrogen peroxide catabolic process; and positive regulation of receptor signaling pathway via JAK-STAT. Located in cytosol; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prx4 in Genome Data Viewer
    Location:
    63A3-63A3; 3-5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3042359..3044174)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3042359..3044174)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene always early Neighboring gene uncharacterized protein Neighboring gene scramblase 2 Neighboring gene Sphingosine kinase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of peroxiredoxin 4 in inflammatory response and aging. Klichko VI, et al. Biochim Biophys Acta, 2016 Feb. PMID 26689888, Free PMC Article
    2. Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila. Rodriguez J, et al. Eur J Biochem, 2000 Jan. PMID 10632718
    3. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. Li D, et al. J Insect Physiol, 2003 Jan. PMID 12770011
    4. Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila. McGinnis A, et al. Antioxidants (Basel), 2021 Apr 15. PMID 33920774, Free PMC Article
    5. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Wangler MF, et al. Protein Cell, 2011 Jul. PMID 21822800, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxiredoxin 4 controls the immune and cell death responses via NF-kappaB analog Relish.
      Title: The role of peroxiredoxin 4 in inflammatory response and aging.
    2. The effects on fly survival and homeostasis appear to represent a combination of differential effects dictated in large part by dPrx4 subcellular and tissue-specific localization.[peroxiredoxin 4]
      Title: The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions.
    3. an IAP antagonist that promotes cell death by liberating Dronc from DIAP1
      Title: Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-dependent peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin 4
    Names
    CG1274-PA
    CG1274-PB
    CG1274-PC
    Prx4-PA
    Prx4-PB
    Prx4-PC
    jafrac2
    peroxiredoxin 4156
    thioredoxin peroxidase
    thioredoxin peroxidase 2
    NP_001261350.1
    NP_525002.1
    NP_728793.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3042359..3044174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080263.4 → NP_525002.1  peroxiredoxin 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525002.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Q4
      Related
      FBpp0072852
      Conserved Domains (1) summary
      cd03015
      Location:52 → 223
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    2. NM_167971.2 → NP_728793.1  peroxiredoxin 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Q4
      Related
      FBpp0072853
      Conserved Domains (1) summary
      cd03015
      Location:52 → 223
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    3. NM_001274421.1 → NP_001261350.1  peroxiredoxin 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Q4
      Conserved Domains (1) summary
      cd03015
      Location:52 → 223
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3Q4 Q9V3Q4

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