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    fws four way stop [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fwsprovided by FlyBase
    Official Full Name
    four way stopprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024689
    Locus tag
    Dmel_CG6549
    See related
    AllianceGenome:FB:FBgn0024689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey162; anon-EST:Posey186; CG6549; Cog5; COG5; dCOG5; Dmel\CG6549; Fws; FWS
    Summary
    Involved in cytoskeleton-dependent cytokinesis; meiotic spindle organization; and spermatid development. Located in Golgi apparatus and endoplasmic reticulum exit site. Part of Golgi transport complex. Is expressed in adult head; embryonic/larval salivary gland; organism; and spermatocyte. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fws in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17478442..17481029, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17478442..17481029, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bicaudal D Neighboring gene small glutamine-rich tetratricopeptide containing protein Neighboring gene cassowary Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene Glucosidase 2 beta subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retrograde transport on the COG railway. Ungar D, et al. Trends Cell Biol, 2006 Feb. PMID 16406524
    2. A dual role for actin and microtubule cytoskeleton in the transport of Golgi units from the nurse cells to the oocyte across ring canals. Nicolas E, et al. Mol Biol Cell, 2009 Jan. PMID 19005218, Free PMC Article
    3. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. Hartwig C, et al. J Neurosci, 2021 Jan 13. PMID 33208468, Free PMC Article
    4. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
    5. The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis. Farkas RM, et al. Mol Biol Cell, 2003 Jan. PMID 12529436, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis II cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid nucleus elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    four way stop
    Names
    CG6549-PA
    CG6549-PC
    CG6549-PD
    CG6549-PH
    CG6549-PI
    Four-way stop
    drosophila Cog5
    four Way stop
    fws-PA
    fws-PC
    fws-PD
    fws-PH
    fws-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17478442..17481029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259130.2 → NP_001246059.1  four way stop, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YG5, Q8T0G3, Q9VJD3
      UniProtKB/TrEMBL
      M9NCV1
      Conserved Domains (1) summary
      pfam10392
      Location:10 → 132
      COG5; Golgi transport complex subunit 5

    2. NM_165221.3 → NP_724058.1  four way stop, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YG5, Q8T0G3, Q9VJD3
      UniProtKB/TrEMBL
      M9NCV1
      Related
      FBpp0080552
      Conserved Domains (1) summary
      pfam10392
      Location:10 → 132
      COG5; Golgi transport complex subunit 5

    3. NM_078866.4 → NP_523590.1  four way stop, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523590.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YG5, Q8T0G3, Q9VJD3
      UniProtKB/TrEMBL
      M9NCV1
      Related
      FBpp0080553
      Conserved Domains (1) summary
      pfam10392
      Location:10 → 132
      COG5; Golgi transport complex subunit 5

    4. NM_001299086.1 → NP_001286015.1  four way stop, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YG5, Q8T0G3, Q9VJD3
      UniProtKB/TrEMBL
      M9NCV1
      Conserved Domains (1) summary
      pfam10392
      Location:10 → 132
      COG5; Golgi transport complex subunit 5

    5. NM_001299087.1 → NP_001286016.1  four way stop, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YG5, Q8T0G3, Q9VJD3
      UniProtKB/TrEMBL
      M9NCV1
      Conserved Domains (1) summary
      pfam10392
      Location:10 → 132
      COG5; Golgi transport complex subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCV1 M9NCV1
    Q9VJD3.1 Q9VJD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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