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    CG6769 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6769provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030878
    Locus tag
    Dmel_CG6769
    See related
    AllianceGenome:FB:FBgn0030878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6769; Vms1
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and mesoderm. Used to study azoospermia. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6769 in Genome Data Viewer
    Location:
    16E2-16E2; 1-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17861002..17862775)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17755035..17756808)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43981 Neighboring gene Sulfiredoxin Neighboring gene Actin-related protein 8 Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis. Geng J, et al. Nat Commun, 2024 Feb 22. PMID 38388640, Free PMC Article
    2. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
    3. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Rimal S, et al. Acta Neuropathol Commun, 2021 Oct 18. PMID 34663454, Free PMC Article
    4. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Yu J, et al. Hum Mol Genet, 2015 Mar 1. PMID 25361961
    5. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6769-PA
    CG6769-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17861002..17862775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272734.1 → NP_001259663.1  uncharacterized protein Dmel_CG6769, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX08
      Conserved Domains (3) summary
      sd00020
      Location:6 → 28
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:70 → 94
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam12756
      Location:191 → 290
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    2. NM_133024.4 → NP_573252.1  uncharacterized protein Dmel_CG6769, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX08
      Related
      FBpp0074267
      Conserved Domains (3) summary
      sd00020
      Location:6 → 28
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:70 → 94
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam12756
      Location:191 → 290
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX08 Q9VX08

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