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    snama something that sticks like glue [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snamaprovided by FlyBase
    Official Full Name
    something that sticks like glueprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086129
    Locus tag
    Dmel_CG3231
    See related
    AllianceGenome:FB:FBgn0086129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21643; BCDNA:LD21643; CG3231; Dmel\CG3231; FBgn0086129; l(2)rQ313; mnm; Snama; SNAMA
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in apoptotic process and cell proliferation involved in compound eye morphogenesis. Predicted to be active in nucleus. Is expressed in adult head; organism; primordial germ cell; and ventral furrow. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See snama in Genome Data Viewer
    Location:
    60B9-60B9; 2-106 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24086604..24092014)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19974127..19979537)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene genghis khan Neighboring gene enoki mushroom

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis. Mather A, et al. Biochim Biophys Acta, 2005 Mar 10. PMID 15733535
    2. Glycolytic flux occurs in Drosophila melanogaster recovering from camptothecin treatment. Hull R, et al. Anticancer Drugs, 2010 Nov. PMID 20717003
    3. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Kwon MJ, et al. Proc Natl Acad Sci U S A, 2018 Nov 6. PMID 30348793, Free PMC Article
    4. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
    5. A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis. Deivasigamani S, et al. Biol Open, 2014 Oct 31. PMID 25361581, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Snama transcripts differentially express during embryogenesis. The putative promoter has potential binding sites for transcription factors that are required for anteroposterior axis formation.
      Title: The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.
    2. mnm as a regulator of mitotic progression during the proliferative phase of eye development, possibly through the control of nucleic acid metabolism
      Title: Characterization of Drosophila mini-me, a gene required for cell proliferation and survival.
    3. SNAMA a hitherto uncharacterized Drosophila protein that appears to play a role in apoptosis.
      Title: SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell proliferation involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    something that sticks like glue
    Names
    CG3231-PA
    CG3231-PB
    lethal (2) rQ313
    mini-me
    retinoblastoma binding protein 6 family
    snama-PA
    snama-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24086604..24092014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138040.4 → NP_611884.1  something that sticks like glue, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ21
      Related
      FBpp0072158
      Conserved Domains (4) summary
      COG5222
      Location:3 → 315
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd00162
      Location:217 → 260
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam08783
      Location:3 → 75
      DWNN; DWNN domain
      pfam13696
      Location:148 → 167
      zf-CCHC_2; Zinc knuckle

    2. NM_001259558.2 → NP_001246487.1  something that sticks like glue, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHU1
      Conserved Domains (4) summary
      COG5222
      Location:3 → 315
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd00162
      Location:217 → 260
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam08783
      Location:3 → 75
      DWNN; DWNN domain
      pfam13696
      Location:148 → 167
      zf-CCHC_2; Zinc knuckle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5SHU1 D5SHU1
    Q9XZ21 Q9XZ21

    Gene LinkOut

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