U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG5003 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43344, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG5003provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039554
    Locus tag
    Dmel_CG5003
    See related
    AllianceGenome:FB:FBgn0039554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5003; FBXL8
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG5003 in Genome Data Viewer
    Location:
    98B5-98B6; 3-94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27913777..27916516, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23739499..23742238, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 98a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene milkah Neighboring gene Buddy of Hmr 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The F-Box Protein CG5003 Regulates Axon Pruning and the Integrity of the Drosophila Mushroom Body. Yang M, et al. Front Mol Neurosci, 2021. PMID 33716667, Free PMC Article
    2. SCF Ligases and Their Functions in Oogenesis and Embryogenesis-Summary of the Most Important Findings throughout the Animal Kingdom. Kinterová V, et al. Cells, 2022 Jan 11. PMID 35053348, Free PMC Article
    3. Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila. Avilés-Pagán EE, et al. G3 (Bethesda), 2020 Sep 2. PMID 32690584, Free PMC Article
    4. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56. Barbosa P, et al. J Cell Biol, 2021 Feb 1. PMID 33382409, Free PMC Article
    5. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG5003-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27913777..27916516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143336.3 → NP_651593.1  uncharacterized protein Dmel_CG5003 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW5, Q9VAZ0
      Related
      FBpp0084641
      Conserved Domains (2) summary
      sd00034
      Location:610 → 635
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:68 → 114
      F-box; F-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSW5 Q8MSW5
    Q9VAZ0 Q9VAZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools