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    Pcif1 Phosphorylated CTD-interacting factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcif1provided by FlyBase
    Official Full Name
    Phosphorylated CTD-interacting factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037021
    Locus tag
    Dmel_CG11399
    See related
    AllianceGenome:FB:FBgn0037021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11399; Dmel\CG11399; dPcif1
    Summary
    Enables RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in wing disc dorsal/ventral pattern formation. Located in nucleus. Orthologous to human PCIF1 (phosphorylated CTD interacting factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pcif1 in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20780350..20786197, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20773450..20779297, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 16 Neighboring gene Peroxin 14 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein Neighboring gene Six4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila. Franco G, et al. RNA, 2023 May. PMID 36754578, Free PMC Article
    2. The Mammalian Cap-Specific m(6)Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues. Pandey RR, et al. Cell Rep, 2020 Aug 18. PMID 32814042
    3. Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. Fisher KH, et al. BMC Genomics, 2012 Sep 24. PMID 23006893, Free PMC Article
    4. A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Bejarano F, et al. Genetics, 2008 Jan. PMID 18202376, Free PMC Article
    5. A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. Fisher KH, et al. J Cell Sci, 2018 Jul 6. PMID 29848658, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila.
      Title: The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II C-terminal domain phosphoserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorylated CTD-interacting factor 1
    Names
    CG11399-PB
    Pcif1-PB
    phosphorylated C-terminal domain (CTD)-interacting factor 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20780350..20786197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140997.3 → NP_649254.2  phosphorylated CTD-interacting factor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649254.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B9, Q9VPB7
      Related
      FBpp0077935
      Conserved Domains (2) summary
      cd00201
      Location:143 → 170
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam12237
      Location:524 → 685
      PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95T03 Q95T03
    Q960B9 Q960B9
    Q9VPB7 Q9VPB7

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