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    Mcm10 Minichromosome maintenance 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35390, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mcm10provided by FlyBase
    Official Full Name
    Minichromosome maintenance 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0032929
    Locus tag
    Dmel_CG9241
    See related
    AllianceGenome:FB:FBgn0032929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9241; dMcm10; Dmel\CG9241; DmMCM10; mcm10; MCM10; Scim19
    Summary
    Predicted to enable DNA replication origin binding activity and single-stranded DNA binding activity. Involved in several processes, including DNA endoreduplication; negative regulation of compound eye retinal cell apoptotic process; and positive regulation of R7 cell differentiation. Located in nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mcm10 in Genome Data Viewer
    Location:
    39B1-39B1; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21179933..21182812)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21179933..21182812)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene burgundy Neighboring gene antisense RNA:CR44911 Neighboring gene Ret oncogene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mcm10 is required for oogenesis and early embryogenesis in Drosophila. Reubens MC, et al. Mech Dev, 2015 Nov. PMID 26369283, Free PMC Article
    2. Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye. Vo N, et al. PLoS One, 2014. PMID 24686397, Free PMC Article
    3. Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles. Apger J, et al. Genetics, 2010 Aug. PMID 20498296, Free PMC Article
    4. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
    5. Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping. Gallone G, et al. BMC Bioinformatics, 2011 Jul 18. PMID 21767381, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of both HP1a and Mcm10 genes inhibited the progression of S phase in eye imaginal discs. Proximity Ligation Assay (PLA) demonstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA polymerase epsilon 255 kDa subunit in S-phase.
      Title: Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation.
    2. Observation of embryonic nuclear morphology and quantification of embryo hatch rates reveal that maternal loading of Mcm10 is required for embryonic nuclear stability, and suggest a role for Mcm10 post zygotic transition.
      Title: Mcm10 is required for oogenesis and early embryogenesis in Drosophila.
    3. Data show that Mcm10 has a role in heterochromatic silencing and chromosome condensation.
      Title: Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of compound eye retinal cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    minichromosome maintenance 10
    Names
    CG9241-PA
    Mcm10-PA
    sensitized chromosome inheritance modifier 19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21179933..21182812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136253.4 → NP_610097.2  minichromosome maintenance 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610097.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RC7, Q9VIE6
      UniProtKB/TrEMBL
      A9UNF9
      Related
      FBpp0081004
      Conserved Domains (2) summary
      pfam09329
      Location:323 → 367
      zf-primase; Primase zinc finger
      pfam09332
      Location:468 → 756
      Mcm10; Mcm10 replication factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIE6.2 Q9VIE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous