Synd Syndapin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Syndprovided by FlyBase
Official Full Name: Syndapinprovided by FlyBase
Primary source: FLYBASE:FBgn0053094
Locus tag: Dmel_CG33094
See related: AllianceGenome:FB:FBgn0053094
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15694; CG33094; D-Synd; Dmel\CG33094; synd
Summary: Enables lipid binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; positive regulation of synaptic assembly at neuromuscular junction; and protein localization to rhabdomere. Located in several cellular components, including cleavage furrow; rhabdomere microvillus; and subsynaptic reticulum. Is expressed in adult head; larval nervous system; larval ventral nerve cord; neuromuscular junction; and organism. Orthologous to several human genes including PACSIN1 (protein kinase C and casein kinase substrate in neurons 1) and PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93A1-93A2; 3-69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20832799..20840118)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16658521..16665840)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos.
Title: F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos.
Synd constricts the microvillus neck resulting in the segregation of the two apical membranes: stalk and rhabdomere
Title: Syndapin constricts microvillar necks to form a united rhabdomere in Drosophila photoreceptors.
study reports Syndapin, a protein containing an F-BAR domain, contributes to remodelling of the plasma membrane around the contractile ring for cytokinesis; Syndapin colocalizes with phosphatidylinositol 4,5-bisphosphate at the cleavage furrow, where it directly interacts with a contractile ring component, Anillin
Title: Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.
Syndapin overexpression greatly expands postsynaptic membrane system.
Title: Syndapin promotes formation of a postsynaptic membrane system in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cleavage furrow ingression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to rhabdomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere membrane biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly involved in male meiosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in subsynaptic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syndapin

Names: CG33094-PB; CG33094-PC; CG33094-PD; Synd-PB; Synd-PC; Synd-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20832799..20840118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275858.1 → NP_001262787.1 syndapin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262787.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH28

Conserved Domains (2) summary

cd07655
Location:17 → 272

F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins

cd11843
Location:441 → 493

SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
NM_176520.2 → NP_788697.1 syndapin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788697.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SZZ4, Q9VDI1

Related

FBpp0083373

Conserved Domains (2) summary

cd07655
Location:17 → 272

F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins

cd11843
Location:440 → 492

SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
NM_001275857.1 → NP_001262786.1 syndapin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262786.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH28

Conserved Domains (2) summary

cd07655
Location:17 → 272

F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins

cd11843
Location:441 → 493

SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins