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    Yif1a Yip1 interacting factor homolog A, membrane trafficking protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yif1aprovided by RGD
    Official Full Name
    Yip1 interacting factor homolog A, membrane trafficking proteinprovided by RGD
    Primary source
    RGD:628749
    See related
    EnsemblRapid:ENSRNOG00000020201 AllianceGenome:RGD:628749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Yif1; Yif1p
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human YIF1A (Yip1 interacting factor homolog A, membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 239.6), Liver (RPKM 187.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Yif1a in Genome Data Viewer
    Location:
    1q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211823921..211828437)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202394923..202399125)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220470070..220474131)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CD248 molecule Neighboring gene transmembrane protein 151A Neighboring gene uncharacterized LOC102555354 Neighboring gene cornichon family AMPA receptor auxiliary protein 2 Neighboring gene RAB1B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites. Kuijpers M, et al. EMBO J, 2013 Jul 17. PMID 23736259, Free PMC Article
    2. A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. Matern H, et al. EMBO J, 2000 Sep 1. PMID 10970842, Free PMC Article
    3. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza L, et al. J Biol Chem, 2004 Nov 5. PMID 15308636
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein YIF1A
    Names
    Yip1p-interacting factor
    liver protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172017.2 → NP_742014.2  protein YIF1A

      See identical proteins and their annotated locations for NP_742014.2

      Status: VALIDATED

      Source sequence(s)
      BF521694, BG377998, CV074812
      UniProtKB/TrEMBL
      A0A8I6GJ16, B0BMV4, F7F3S4
      Related
      ENSRNOP00000027406.4, ENSRNOT00000027406.8
      Conserved Domains (1) summary
      pfam03878
      Location:57 → 288
      YIF1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211823921..211828437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089976.2 → XP_038945904.1  protein YIF1A isoform X2

      Conserved Domains (1) summary
      cl21557
      Location:12 → 156
      Yip1; Yip1 domain

    2. XM_063276968.1 → XP_063133038.1  protein YIF1A isoform X1

      UniProtKB/TrEMBL
      A6HZ25
    Nucleotide Protein Strain
    Heading Accession and Version

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