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    Cd22 CD22 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd22provided by MGI
    Official Full Name
    CD22 antigenprovided by MGI
    Primary source
    MGI:MGI:88322
    See related
    Ensembl:ENSMUSG00000030577 AllianceGenome:MGI:88322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyb8; Lyb-8; A530093D23
    Summary
    Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 81.5), mammary gland adult (RPKM 20.6) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd22 in Genome Data Viewer
    Location:
    7 B1; 7 19.26 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30564829..30579767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30865404..30880342, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 3 Neighboring gene free fatty acid receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6534 Neighboring gene DNA segment, Chr 7, ERATO Doi 128, expressed Neighboring gene STARR-positive B cell enhancer ABC_E1732 Neighboring gene myelin-associated glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. Sato M, et al. J Immunol, 2007 Mar 1. PMID 17312134
    2. CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. Matsubara N, et al. Front Immunol, 2018. PMID 29725338, Free PMC Article
    3. Reduction of marginal zone B cells in CD22-deficient mice. Samardzic T, et al. Eur J Immunol, 2002 Feb. PMID 11828373
    4. Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. Jin L, et al. J Exp Med, 2002 May 6. PMID 11994425, Free PMC Article
    5. Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22. Mills DM, et al. J Immunol, 2004 Jan 1. PMID 14688326

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
      Title: Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
    2. CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.
      Title: CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.
    3. The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
      Title: The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
    4. CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.
      Title: CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.
    5. CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output.
      Title: CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output.
    6. A CD22-Shp1 phosphatase axis controls integrin beta7 display and B cell function in mucosal immunity.
      Title: A CD22-Shp1 phosphatase axis controls integrin β(7) display and B cell function in mucosal immunity.
    7. Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.
      Title: Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.
    8. Humanized CD22 transgenic mouse model for in vivo analysis of anti-CD22-based immunotherapy.
      Title: Humanized CD22 transgenic mouse model for in vivo analysis of anti-CD22-based immunotherapy.
    9. CD22 and CD72 contribute to the development of scleroderma in a murine model.
      Title: CD22 and CD72 contribute to the development of scleroderma in a murine model.
    10. N-Linked Glycosylation Regulates CD22 Organization and Function.
      Title: N-Linked Glycosylation Regulates CD22 Organization and Function.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CD4 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coreceptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialic acid binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell receptor CD22
    Names
    B-lymphocyte cell adhesion molecule
    BL-CAM
    T-cell surface antigen Leu-14
    sialic acid-binding Ig-like lectin 2
    siglec-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043317.2 → NP_001036782.1  B-cell receptor CD22 precursor

      See identical proteins and their annotated locations for NP_001036782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer protein-coding transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165340, AK143835
      Consensus CDS
      CCDS21114.1
      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000139871.2, ENSMUST00000190617.7
      Conserved Domains (3) summary
      smart00408
      Location:366 → 424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260 → 334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153 → 239
      Ig; Immunoglobulin domain

    2. NM_009845.3 → NP_033975.3  B-cell receptor CD22 precursor

      See identical proteins and their annotated locations for NP_033975.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165340, AK143835
      Consensus CDS
      CCDS21114.1
      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000019248.7, ENSMUST00000019248.13
      Conserved Domains (3) summary
      smart00408
      Location:366 → 424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260 → 334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153 → 239
      Ig; Immunoglobulin domain

    RNA

    1. NR_102722.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165340, AK041230

    2. NR_102723.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165340, BC046957

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30564829..30579767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539493.1 → XP_006539556.1  B-cell receptor CD22 isoform X2

      See identical proteins and their annotated locations for XP_006539556.1

      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000139685.2, ENSMUST00000186154.7
      Conserved Domains (3) summary
      smart00408
      Location:366 → 424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260 → 334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153 → 239
      Ig; Immunoglobulin domain

    2. XM_006539490.1 → XP_006539553.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539553.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377 → 435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271 → 345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164 → 250
      Ig; Immunoglobulin domain

    3. XM_006539491.3 → XP_006539554.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539554.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377 → 435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271 → 345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164 → 250
      Ig; Immunoglobulin domain

    4. XM_006539489.4 → XP_006539552.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539552.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377 → 435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271 → 345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164 → 250
      Ig; Immunoglobulin domain

    RNA

    1. XR_391039.4 RNA Sequence

      Related
      ENSMUST00000190646.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35329.2 GenPept UniProtKB/Swiss-Prot:P35329

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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