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    Ranbp2 RAN binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19386, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ranbp2provided by MGI
    Official Full Name
    RAN binding protein 2provided by MGI
    Primary source
    MGI:MGI:894323
    See related
    Ensembl:ENSMUSG00000003226 AllianceGenome:MGI:894323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NUP358; A430087B05Rik
    Summary
    Enables SUMO transferase activity. Involved in nuclear export. Acts upstream of or within positive regulation of glucokinase activity and regulation of gluconeogenesis. Predicted to be located in annulate lamellae; cytoplasmic periphery of the nuclear pore complex; and nucleus. Predicted to be part of SUMO ligase complex; nuclear pore cytoplasmic filaments; and nuclear pore nuclear basket. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to several human genes including RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 9.3), placenta adult (RPKM 8.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ranbp2 in Genome Data Viewer
    Location:
    10 B4; 10 29.34 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58282674..58329977)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58446852..58494155)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2935 Neighboring gene GRIP and coiled-coil domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E575 Neighboring gene STARR-seq mESC enhancer starr_26754 Neighboring gene STARR-positive B cell enhancer ABC_E6854 Neighboring gene LIM and senescent cell antigen-like domains 1 Neighboring gene predicted gene, 23058 Neighboring gene STARR-positive B cell enhancer ABC_E2936 Neighboring gene STARR-positive B cell enhancer ABC_E10608 Neighboring gene coiled-coil domain containing 138 Neighboring gene STARR-positive B cell enhancer ABC_E10609 Neighboring gene STARR-seq mESC enhancer starr_26758 Neighboring gene predicted gene, 18042 Neighboring gene ectodysplasin-A receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SUMO ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear export EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    located_in annulate lamellae ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic periphery of the nuclear pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic periphery of the nuclear pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore cytoplasmic filaments IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore cytoplasmic filaments ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 SUMO-protein ligase RanBP2
    Names
    E3 SUMO-protein transferase RanBP2
    ran-binding protein 2
    NP_035370.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011240.3NP_035370.2  E3 SUMO-protein ligase RanBP2

      See identical proteins and their annotated locations for NP_035370.2

      Status: VALIDATED

      Source sequence(s)
      AC158593
      Consensus CDS
      CCDS23861.1
      UniProtKB/Swiss-Prot
      E9QM01, Q61992, Q8C9K9, Q9ERU9
      Related
      ENSMUSP00000003310.6, ENSMUST00000003310.7
      Conserved Domains (12) summary
      cd01926
      Location:28933051
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd13177
      Location:18641980
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd13178
      Location:27542870
      RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
      cd14684
      Location:11801296
      RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
      cd14685
      Location:21612277
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00025
      Location:13501369
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam00641
      Location:14691498
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam12185
      Location:25442602
      IR1-M; Nup358/RanBP2 E3 ligase domain
      pfam13414
      Location:59126
      TPR_11; TPR repeat
      cl23782
      Location:839925
      RCR; Chitin synthesis regulation, resistance to Congo red

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      58282674..58329977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)