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    Paip1 polyadenylate binding protein-interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 218693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paip1provided by MGI
    Official Full Name
    polyadenylate binding protein-interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2384993
    See related
    Ensembl:ENSMUSG00000025451 AllianceGenome:MGI:2384993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAIP-1
    Summary
    Predicted to enable translation activator activity. Predicted to be involved in positive regulation by host of viral process and post-transcriptional regulation of gene expression. Predicted to act upstream of with a positive effect on viral translation. Predicted to be located in cytosol. Predicted to be part of mCRD-mediated mRNA stability complex. Predicted to be active in cytoplasm. Is expressed in medial ganglionic eminence. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.1), adrenal adult (RPKM 8.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paip1 in Genome Data Viewer
    Location:
    13 D2.3; 13 67.22 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (119564960..119596858)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119428331..119460323)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35797 Neighboring gene STARR-seq mESC enhancer starr_35799 Neighboring gene STARR-seq mESC enhancer starr_35800 Neighboring gene STARR-seq mESC enhancer starr_35802 Neighboring gene STARR-seq mESC enhancer starr_35803 Neighboring gene STARR-seq mESC enhancer starr_35804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:120196902-120197103 Neighboring gene RIKEN cDNA 4833420G17 gene Neighboring gene STARR-positive B cell enhancer ABC_E7292 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene RIKEN cDNA 3110070M22 gene Neighboring gene STARR-seq mESC enhancer starr_35805 Neighboring gene predicted gene 9752 Neighboring gene transmembrane protein 267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma. Xie H, et al. Head Neck, 2020 Dec. PMID 32827170
    2. Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†. He Y, et al. Biol Reprod, 2019 Feb 1. PMID 30295753
    3. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1. Yin G, et al. Arch Biochem Biophys, 2024 Apr. PMID 38341068
    4. Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Martineau Y, et al. Mol Cell Biol, 2014 Mar. PMID 24396066, Free PMC Article
    5. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
      Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    2. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
      Title: Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
    3. PAIP1 regulates the translation of YBX2-masked mRNAs during spermiogenesis.
      Title: Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect viral translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of mCRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein-interacting protein 1
    Names
    PABP-interacting protein 1
    poly(A)-binding protein-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079849.3 → NP_001073318.1  polyadenylate-binding protein-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001073318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC163689
      Consensus CDS
      CCDS36791.1
      UniProtKB/TrEMBL
      D3Z3J6
      Related
      ENSMUSP00000104826.3, ENSMUST00000109203.9
      Conserved Domains (1) summary
      pfam02854
      Location:48 → 264
      MIF4G; MIF4G domain

    2. NM_145457.5 → NP_663432.1  polyadenylate-binding protein-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_663432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163689
      Consensus CDS
      CCDS26796.1
      UniProtKB/Swiss-Prot
      Q8VE62, Q9WUC9
      UniProtKB/TrEMBL
      F6Y616
      Related
      ENSMUSP00000026520.8, ENSMUST00000026520.14
      Conserved Domains (1) summary
      pfam02854
      Location:81 → 297
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      119564960..119596858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE62.1 GenPept UniProtKB/Swiss-Prot:Q8VE62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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