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    Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 79560, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ublcp1provided by MGI
    Official Full Name
    ubiquitin-like domain containing CTD phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1933105
    See related
    Ensembl:ENSMUSG00000041231 AllianceGenome:MGI:1933105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930527B16Rik; 8430435I17Rik
    Summary
    Predicted to enable proteasome regulatory particle binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ATP-dependent activity and regulation of proteasome assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in ductus deferens and testis. Orthologous to human UBLCP1 (ubiquitin like domain containing CTD phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 11.4), placenta adult (RPKM 10.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ublcp1 in Genome Data Viewer
    Location:
    11 B1.1; 11 25.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (44345398..44361540, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (44454571..44470713, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29271 Neighboring gene predicted gene 12153 Neighboring gene STARR-seq mESC enhancer starr_29272 Neighboring gene STARR-seq mESC enhancer starr_29274 Neighboring gene STARR-seq mESC enhancer starr_29278 Neighboring gene STARR-seq mESC enhancer starr_29279 Neighboring gene interleukin 12b Neighboring gene STARR-positive B cell enhancer ABC_E5216 Neighboring gene STARR-positive B cell enhancer mm9_chr11:44292046-44292346 Neighboring gene STARR-positive B cell enhancer ABC_E3941 Neighboring gene STARR-positive B cell enhancer ABC_E6969 Neighboring gene STARR-positive B cell enhancer ABC_E8391 Neighboring gene adenosine kinase pseudogene Neighboring gene ring finger protein 145 Neighboring gene predicted gene, 51891

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC7513, MGC117826

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteasome regulatory particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteasome regulatory particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of proteasome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like domain-containing CTD phosphatase 1
    Names
    nuclear proteasome inhibitor UBLCP1
    NP_077795.2
    XP_006534585.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024475.5NP_077795.2  ubiquitin-like domain-containing CTD phosphatase 1

      See identical proteins and their annotated locations for NP_077795.2

      Status: VALIDATED

      Source sequence(s)
      AK147744, BQ177022, CJ061422
      Consensus CDS
      CCDS24564.1
      UniProtKB/Swiss-Prot
      A2ACX3, Q52L62, Q5XJH1, Q6PH96, Q8BGR9, Q99LT3
      Related
      ENSMUSP00000099859.4, ENSMUST00000102795.4
      Conserved Domains (2) summary
      TIGR02245
      Location:117311
      HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
      cd01813
      Location:377
      Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      44345398..44361540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534522.4XP_006534585.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534585.1

      UniProtKB/Swiss-Prot
      A2ACX3, Q52L62, Q5XJH1, Q6PH96, Q8BGR9, Q99LT3
      Conserved Domains (2) summary
      TIGR02245
      Location:117311
      HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
      cd01813
      Location:377
      Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins