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    Stard3 StAR related lipid transfer domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 59045, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stard3provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 3provided by MGI
    Primary source
    MGI:MGI:1929618
    See related
    Ensembl:ENSMUSG00000018167 AllianceGenome:MGI:1929618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    es64; Mln64
    Summary
    Predicted to enable cholesterol binding activity and protein homodimerization activity. Acts upstream of or within progesterone biosynthetic process. Located in endosome and mitochondrion. Is expressed in nervous system. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.5), colon adult (RPKM 38.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stard3 in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98249245..98271938)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98358367..98381112)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1147 Neighboring gene predicted gene, 38970 Neighboring gene RIKEN cDNA 1700003D09 gene Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1B Neighboring gene STARR-positive B cell enhancer ABC_E7055 Neighboring gene STARR-positive B cell enhancer ABC_E7056 Neighboring gene titin-cap Neighboring gene phenylethanolamine-N-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cholesterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within progesterone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle tethering to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle tethering to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-endosome membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    stAR-related lipid transfer protein 3
    Names
    START domain containing 3
    START domain-containing protein 3
    protein ES 64
    protein MLN 64
    steroidogenic acute regulatory protein related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425637.1NP_001412566.1  stAR-related lipid transfer protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591390
    2. NM_001425638.1NP_001412567.1  stAR-related lipid transfer protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591390
      UniProtKB/Swiss-Prot
      Q61542
      UniProtKB/TrEMBL
      Q544C3
    3. NM_001425639.1NP_001412568.1  stAR-related lipid transfer protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591390
    4. NM_001425640.1NP_001412569.1  stAR-related lipid transfer protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591390
    5. NM_021547.4NP_067522.1  stAR-related lipid transfer protein 3 isoform 1

      See identical proteins and their annotated locations for NP_067522.1

      Status: VALIDATED

      Source sequence(s)
      AL591390
      Consensus CDS
      CCDS25345.1
      UniProtKB/Swiss-Prot
      Q61542
      UniProtKB/TrEMBL
      Q544C3
      Related
      ENSMUSP00000018311.5, ENSMUST00000018311.5
      Conserved Domains (2) summary
      cd08906
      Location:234442
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:48213
      MENTAL; Cholesterol-capturing domain

    RNA

    1. NR_189333.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591390
      Related
      ENSMUST00000154960.8
    2. NR_189334.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591390

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98249245..98271938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533895.5XP_006533958.1  stAR-related lipid transfer protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006533958.1

      Conserved Domains (2) summary
      cd08906
      Location:255463
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:48234
      MENTAL; Cholesterol-capturing domain