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    Hnrnpm heterogeneous nuclear ribonucleoprotein M [ Mus musculus (house mouse) ]

    Gene ID: 76936, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hnrnpmprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Mprovided by MGI
    Primary source
    MGI:MGI:1926465
    See related
    Ensembl:ENSMUSG00000059208 AllianceGenome:MGI:1926465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpm; mKIAA4193; 2610023M21Rik
    Summary
    Predicted to enable several functions, including calcium-dependent protein binding activity; mRNA binding activity; and protein antigen binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; positive regulation of protein localization; and regulation of postsynapse organization. Located in collagen-containing extracellular matrix. Is active in synapse. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and olfactory epithelium. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 154.1), liver E14 (RPKM 82.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hnrnpm in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33865207..33904432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33646233..33685458, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene zinc finger protein 414 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in paraspeckles IEA
    Inferred from Electronic Annotation
    more info
     
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein M
    Names
    hnRNP M

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109913.1NP_001103383.1  heterogeneous nuclear ribonucleoprotein M isoform b

      See identical proteins and their annotated locations for NP_001103383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1, which results in shorter protein (isoform b) when compared to isoform a.
      Source sequence(s)
      AK220299, BC054785
      Consensus CDS
      CCDS50068.1
      UniProtKB/TrEMBL
      Q3THB3, Q3TW40
      Related
      ENSMUSP00000084864.6, ENSMUST00000087582.13
      Conserved Domains (5) summary
      COG0724
      Location:615690
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:166239
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:614690
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4069
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:71146
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_029804.3NP_084080.1  heterogeneous nuclear ribonucleoprotein M isoform a

      See identical proteins and their annotated locations for NP_084080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK220299, BC054785
      Consensus CDS
      CCDS37570.1
      UniProtKB/Swiss-Prot
      Q6P1B2, Q99JQ0, Q9D0E1
      UniProtKB/TrEMBL
      Q3TW40
      Related
      ENSMUSP00000120115.2, ENSMUST00000148178.8
      Conserved Domains (5) summary
      COG0724
      Location:654729
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:205278
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:71146
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:653729
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4069
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33865207..33904432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)