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    Fbxl3 F-box and leucine-rich repeat protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 50789, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fbxl3provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 3provided by MGI
    Primary source
    MGI:MGI:1354702
    See related
    Ensembl:ENSMUSG00000022124 AllianceGenome:MGI:1354702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBK; Ovtm; Fbl3a; Fbxl3a; Play68
    Summary
    Contributes to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Located in cytosol and nucleus. Is expressed in embryo; extraembryonic component; inner cell mass; and trophectoderm. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 14.1), bladder adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl3 in Genome Data Viewer
    Location:
    14 E2.3; 14 51.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (103318470..103337016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (103080239..103099566, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37495 Neighboring gene STARR-positive B cell enhancer mm9_chr14:103464914-103465215 Neighboring gene STARR-positive B cell enhancer ABC_E7347 Neighboring gene predicted gene, 41236 Neighboring gene STARR-seq mESC enhancer starr_37499 Neighboring gene STARR-positive B cell enhancer ABC_E11579 Neighboring gene STARR-seq mESC enhancer starr_37500 Neighboring gene ceroid-lipofuscinosis, neuronal 5 Neighboring gene STARR-seq mESC enhancer starr_37501 Neighboring gene MYC binding protein 2, E3 ubiquitin protein ligase Neighboring gene RIKEN cDNA 1700087I21 gene Neighboring gene STARR-positive B cell enhancer mm9_chr14:103745967-103746268 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:103748726-103748913 Neighboring gene STARR-positive B cell enhancer ABC_E10839

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 3
    Names
    F-box and leucine-rich repeat protein 3a
    F-box/LRR-repeat protein 3A
    protein after-hours
    protein overtime

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347600.2NP_001334529.1  F-box/LRR-repeat protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC102815
      Consensus CDS
      CCDS84159.1
      UniProtKB/TrEMBL
      Q3TJJ7
      Conserved Domains (2) summary
      sd00034
      Location:126151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3669
      F-box-like
    2. NM_001347601.2NP_001334530.1  F-box/LRR-repeat protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC102815
      Consensus CDS
      CCDS84159.1
      UniProtKB/TrEMBL
      Q3TJJ7
      Related
      ENSMUSP00000115843.2, ENSMUST00000132004.8
      Conserved Domains (2) summary
      sd00034
      Location:126151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3669
      F-box-like
    3. NM_001360341.2NP_001347270.1  F-box/LRR-repeat protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102815
      Consensus CDS
      CCDS27315.1
      UniProtKB/Swiss-Prot
      Q80V32, Q8C4V4, Q8K1W0, Q9QXW1
      UniProtKB/TrEMBL
      Q3TJJ7, Q5PRF6
      Related
      ENSMUSP00000116044.2, ENSMUST00000145693.8
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
    4. NM_001360342.2NP_001347271.1  F-box/LRR-repeat protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102815
      Consensus CDS
      CCDS27315.1
      UniProtKB/Swiss-Prot
      Q80V32, Q8C4V4, Q8K1W0, Q9QXW1
      UniProtKB/TrEMBL
      Q3TJJ7, Q5PRF6
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
    5. NM_001424673.1NP_001411602.1  F-box/LRR-repeat protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102815
      UniProtKB/TrEMBL
      Q3TJJ7
    6. NM_001424674.1NP_001411603.1  F-box/LRR-repeat protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102815
      UniProtKB/TrEMBL
      Q8BNS3
    7. NM_001424675.1NP_001411604.1  F-box/LRR-repeat protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102815
      UniProtKB/TrEMBL
      Q8BNS3
    8. NM_015822.4NP_056637.1  F-box/LRR-repeat protein 3 isoform 1

      See identical proteins and their annotated locations for NP_056637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC102815
      Consensus CDS
      CCDS27315.1
      UniProtKB/Swiss-Prot
      Q80V32, Q8C4V4, Q8K1W0, Q9QXW1
      UniProtKB/TrEMBL
      Q3TJJ7, Q5PRF6
      Related
      ENSMUSP00000022720.9, ENSMUST00000022720.15
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      103318470..103337016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)