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    Pnmt phenylethanolamine-N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 18948, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnmtprovided by MGI
    Official Full Name
    phenylethanolamine-N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:97724
    See related
    Ensembl:ENSMUSG00000038216 AllianceGenome:MGI:97724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pent
    Summary
    Enables phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to be located in axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 262.6) See more
    Orthologs
    NEW
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    Genomic context

    See Pnmt in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98277449..98279006)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98386623..98388180)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7056 Neighboring gene StAR related lipid transfer domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene titin-cap Neighboring gene post-GPI attachment to proteins 3 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene migration and invasion enhancer 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phenylethanolamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phenylethanolamine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phenylethanolamine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in epinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phenylethanolamine N-methyltransferase
    Names
    PNMTase
    noradrenaline N-methyltransferase
    NP_032916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008890.3NP_032916.1  phenylethanolamine N-methyltransferase

      See identical proteins and their annotated locations for NP_032916.1

      Status: VALIDATED

      Source sequence(s)
      AL591390
      Consensus CDS
      CCDS25347.1
      UniProtKB/Swiss-Prot
      P40935
      UniProtKB/TrEMBL
      Q0VB50
      Related
      ENSMUSP00000035549.8, ENSMUST00000041301.8
      Conserved Domains (1) summary
      pfam01234
      Location:25290
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98277449..98279006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)