U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B [ Mus musculus (house mouse) ]

    Gene ID: 19049, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp1r1bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory inhibitor subunit 1Bprovided by MGI
    Primary source
    MGI:MGI:94860
    See related
    Ensembl:ENSMUSG00000061718 AllianceGenome:MGI:94860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Darpp32; DARPP-32
    Summary
    This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in duodenum adult (RPKM 153.3), large intestine adult (RPKM 145.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r1b in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98239232..98248622)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98348406..98357796)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33099 Neighboring gene STARR-positive B cell enhancer ABC_E1147 Neighboring gene predicted gene, 38970 Neighboring gene RIKEN cDNA 1700003D09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7055 Neighboring gene STARR-positive B cell enhancer ABC_E7056 Neighboring gene StAR related lipid transfer domain containing 3 Neighboring gene titin-cap

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D2 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D3 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D4 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D5 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine/threonine phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of female receptivity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine neck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 1B
    Names
    dopamine- and cAMP-regulated neuronal phosphoprotein
    NP_001300899.1
    NP_659077.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313970.1NP_001300899.1  protein phosphatase 1 regulatory subunit 1B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1.This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AY640620, BU700812
      Consensus CDS
      CCDS83889.1
      UniProtKB/Swiss-Prot
      Q60829
      Related
      ENSMUSP00000123528.2, ENSMUST00000137634.2
      Conserved Domains (1) summary
      pfam05395
      Location:171
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
    2. NM_144828.2NP_659077.1  protein phosphatase 1 regulatory subunit 1B isoform 1

      See identical proteins and their annotated locations for NP_659077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141563, BU700812, CX239932, CX240293
      Consensus CDS
      CCDS25344.1
      UniProtKB/Swiss-Prot
      A2A564, Q3URF2, Q60829, Q6DV86, Q91XB5
      Related
      ENSMUSP00000077760.7, ENSMUST00000078694.13
      Conserved Domains (1) summary
      pfam05395
      Location:2107
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98239232..98248622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)