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    Ugt8 UDP glycosyltransferase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt8provided by RGD
    Official Full Name
    UDP glycosyltransferase 8provided by RGD
    Primary source
    RGD:3938
    See related
    EnsemblRapid:ENSRNOG00000009345 AllianceGenome:RGD:3938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CGalT; Ugt8a
    Summary
    Enables N-acylsphingosine galactosyltransferase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in galactosylceramide biosynthetic process and response to immobilization stress. Located in endoplasmic reticulum. Orthologous to human UGT8 (UDP glycosyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 452.3), Kidney (RPKM 63.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ugt8 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (216938884..217007167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (214264483..214332769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (229644373..229718678, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 6 Neighboring gene N-deacetylase and N-sulfotransferase 4 Neighboring gene ribosomal protein L7, pseudogene 17 Neighboring gene zinc finger and BTB domain-containing protein 7B-like Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 9 Neighboring gene uncharacterized LOC108350105 Neighboring gene arylsulfatase family, member J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. van der Bijl P, et al. Biochem J, 1996 Jul 15. PMID 8713090, Free PMC Article
    2. Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. Schulte S, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 7694285, Free PMC Article
    3. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase. Stahl N, et al. J Neurosci Res, 1994 Jun 1. PMID 7521399
    4. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. Dupree JL, et al. J Neurosci, 1998 Mar 1. PMID 9464989, Free PMC Article
    5. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Coetzee T, et al. Cell, 1996 Jul 26. PMID 8706126

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acylsphingosine galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylsphingosine galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in galactosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactosylceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactosylceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in myelination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in paranodal junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-hydroxyacylsphingosine 1-beta-galactosyltransferase
    Names
    UDP galactosyltransferase 8
    UDP galactosyltransferase 8A
    UDP-galactose-ceramide galactosyltransferase 8
    UDP-glucuronosyltransferase 8
    ceramide UDP-galactosyltransferase
    cerebroside synthase
    NP_062149.1
    XP_017446541.1
    XP_063138484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019276.3 → NP_062149.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

      See identical proteins and their annotated locations for NP_062149.1

      Status: VALIDATED

      Source sequence(s)
      BF551096, BG671666, U07683
      UniProtKB/Swiss-Prot
      Q09426
      UniProtKB/TrEMBL
      A6HVK3
      Related
      ENSRNOP00000012676.2, ENSRNOT00000012676.6
      Conserved Domains (2) summary
      PHA03392
      Location:8 → 490
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:21 → 502
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      216938884..217007167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591052.3 → XP_017446541.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09426
      UniProtKB/TrEMBL
      A6HVK3
      Conserved Domains (2) summary
      PHA03392
      Location:8 → 490
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:21 → 502
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    2. XM_063282414.1 → XP_063138484.1  2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09426
      UniProtKB/TrEMBL
      A6HVK3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09426.1 GenPept UniProtKB/Swiss-Prot:Q09426

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